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A new model of depression induced by psychogenic stress

  • Comparative and Ontogenic Physiology
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Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

Abstract

A new model of depression based on use of stressors of the psychogenic nature has been created. It turned out that laboratory rats in a special stress-camera were unable to elaborate bilateral reaction of active avoidance, which later on led to formation of their depression-like state. Development of such their state was confirmed by analysis of tests sensitive to depression: forced swimming and tail suspension, dynamics of the animal body mass and their behavior on the whole. This model has turned out to be sensitive to a selective inhibitor of the serotonin uptake—fluoxetine, which also confirms that our obtained model is the model of depression.

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References

  1. Doris, A., Ebmeier, K., and Shajahan, P, Depressive Illness, Lancet, 1999, no. 354, pp. 1369–1375.

  2. Lucca, G., Comim, C.M., Valvassori, S.S., Reus, G.Z., Vuolo, F., Petronilho, F., Dal-Pizzol, F., Gavioli, E.C., and Quevedo, J., Effects of Chronic Mild Stress on the Oxidative Parameters in the Rat Brain, Neurochem Int., 2009, vol. 54, no. 5–6. pp. 358–362.

    Article  PubMed  CAS  Google Scholar 

  3. Palanza, P., Animal Models of Anxiety and Depression: How Are Females Different?, Neurosci. Biobehav. Rev., 2001, vol. 25, no. 3, pp. 219–233.

    Article  PubMed  CAS  Google Scholar 

  4. Krupina, I.A., Orlova, I.I., and Kryzhanovskii, G.N., Method of Integral Estimation of Expression of Depression of Rat Behavior, Zh. Vyssh. Nerv. Deyat., 1999, no. 5. pp. 864–875.

  5. Kalueff, A.V., Principles of Experimental Modeling of the Anxiety-Depression Pathogenesis, Neuronauki, 2006, vol. 3, no. 1, pp. 34–56.

    Google Scholar 

  6. Fisch, G.S., Animal Models and Human Neuropsychiatric Disorders, Behav. Genet., 2007, vol. 37, pp. 1–10.

    Article  PubMed  Google Scholar 

  7. Hinojosa, F.R., Spricigo, L., Jr, Izido, G.S., Bruske, G.R., Lopes, D.M,, and Ramos, A., Evaluation of two Genetic Animal Models in Behavioral Tests of Anxiety and Depression, Behav. Brain Res., 2006, vol. 168, no. 1, pp. 127–136.

    Article  PubMed  Google Scholar 

  8. Holmes, P.V., Rodent Models of Depression: Reexamining Validity without Anthropomorphic Interference, Crit. Rev. Neurobiol., 2003, vol. 15, pp. 142–174.

    Article  Google Scholar 

  9. Matthews, K., Christmas, D., Swan, J., and Sorrell, E., Animal Models of Depression: Navigating through the Clinical Fog, Neurosci. Biobehav. Rev., 2005, vol. 29, pp. 503–513.

    Article  PubMed  Google Scholar 

  10. Newport, D.J., Stowe, Z.N., and Nemeroff, C.B., Parental Depression: Animal Models of an Adverse Life Event, Am. J. Psychiat., 2002. vol. 159, pp. 1265–1283.

    Article  PubMed  Google Scholar 

  11. Overall, K.L., Natural Animal Models of Human Psychiatry Conditions: Assessment of Mechanisms and Validity, Prog. Neuro-Psychopharm. Biol. Psych., 2000, vol. 24, pp. 727–776.

    Article  CAS  Google Scholar 

  12. Overmier, J.B., On the Nature of Animal Models of Human Behavioral Disfunction, Animal Models of Human Emotion and Cognition, Haug, M. and Whalen, R.E., Eds., Washington, 1999, pp. 15–24.

  13. Petters, R.M. and Sommer, J.R., Transgenic Animals as Models for Human Disease, Transgenic Res., 2000, vol. 9, no. 4–5, pp. 347–351.

    Article  PubMed  CAS  Google Scholar 

  14. Phillips, T.J., Belknap, J.K., Hitzemann, R.J., Buck, K.J., Cunningham, C.L., and Crabbe, J.C., Harnessing the Mouse to Unravel the Genetics of Human Disease, Genes Brain Behav., 2002, vol. 1, no. 1, pp. 14–28.

    Article  PubMed  CAS  Google Scholar 

  15. Rand, M.S., Selection of Biomedical Animal Models, Sourcebook of Models for Biomedical Research, Conn, P.M. and Totowa, N.J., Eds., Humana Press, 2008.

  16. Rezvani, A.K., Parsian, A., and Overstreet, D.H., The Fawn-Hooded (FH/Wjd) Rat: a Genetic Animal Model of Comorbid Depression and Alcoholism, Psychiat. Genet., 2002, vol. 12, no. l, pp. 1–16.

    Article  Google Scholar 

  17. Rodgers, R.J., Cao, B.-J., Dalvi, A., and Holmes, A., Animal Models of Anxiety: an Ethological Perspective, Braz. J. Med. Biol. Res., 1997, vol. 30, pp. 289–304.

    Article  PubMed  CAS  Google Scholar 

  18. Sarter, M. and Bruno, J.P., Animal Models in Biological Psychiatry, Biological Psychiatry, D’haenen, H., den Boer, J.A., and Willner, P., Eds., Willey and Sons, New York, 2002, pp. 1–8.

    Google Scholar 

  19. Van der Staay, F.J., Arndt, S.S., and Nordquist, R.E., Evaluation of Animal Models of Neurobehavioral Disorders, Behav. Brain Funct., 2009, no. 5. p. 11.

  20. Avgustinovich, D.F., Alekseenko, O.V., Bakshtanovskaya, I.V, Koryakina, L.A., Lipina, T.V., Tenditnik, M.V., Bondar, N.P., Kovalenko, I.L., and Kudryavtseva, N.N., Dynamic Changes of Serotoninergic and Dopaminergic Brain Activity in the Process of Development of Anxiety Depression: Experimental Study, Usp. Fiziol. Nauk, 2004, vol. 35, no. 4, pp. 19–40.

    PubMed  CAS  Google Scholar 

  21. Rojo-Moreno, L., Livianos-Aldana, L., Cervera-Martinez, G., Dominguez-Carabantes, J.A., and Reig-Cebrian, M.J., The Role of Stress in the Onset of Depressive Disorders. A Controlled Study in a Spanish Clinical Sample, Soc. Psychiatry Psychiat. Epidemiol., 2002, vol. 37, no. 12, pp. 592–598.

    Article  CAS  Google Scholar 

  22. Kalueff, A.V., Today and Tomorrow of Anxiety Research, Stress Behav., 2003, vol. 8, pp. 145–147.

    Google Scholar 

  23. Willner, P. and Mitchell, P.J., The validity of Animal Model of Predisposition to Depression, Behav. Pharmacol., 2002, vol. 13, no. 3, pp. 169–188.

    Article  PubMed  CAS  Google Scholar 

  24. Willner, P., Validity, Reliability and Utility of Chronic Mild Stress Model of Depression: a 10-Year Review and Evaluation, Psychopharmacol. (Berlin), 1997, vol. 134, no. 4, pp. 319–329.

    Article  CAS  Google Scholar 

  25. Khananashvili, M.M., Problem of Transitional State from Norm to Pathology in Theory of the Higher Nervous Activity, Patol. Fiziol. Eksper. Terap., 2007, no. 2, pp. 2–6.

  26. Khananashvili, M.M, Psychogenic Stress: Theory, Experiment, Practice, Vestn. RAMN, 1998, no. 8, pp. 13–16.

  27. Kalueff, A.V. and Tuohimaa, P., Experimental Modeling of Anxiety and Depression, Acta Neurobiol. Exp. (Wars.), 2004, vol. 64, no. 4, pp. 439–448.

    Google Scholar 

  28. Song, C. and Leonard, B.E., The Olfactory Bulbectomised Rat as a Model of Depression, Neurosci. Biobehav. Rev., 2005, vol. 29, pp. 627–647.

    Article  PubMed  Google Scholar 

  29. Tasset, I., Peña, J., Jimena, I., Feijóo, M., Muñoz, M.C., Montilla, P., and Túnez, I., Effect of 17β-Estradiol on Olfactory Bulbectomy-Induced Oxidative Stress and Behavioral Changes in Rats, Neuropsychiatr. Dis. Treat., 2008, vol. 4, no. 2, pp. 441–449.

    PubMed  CAS  Google Scholar 

  30. Túnez, I., Medina, F.J., Jimena, I., Muñoz, M.C, Peña, J., Tasset, I., and Montilla, P., Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression, Lett. Drug. Des. Discov. 2007, vol. 4, no. 4, pp. 305–310.

    Article  Google Scholar 

  31. Túnez, I., Drucker-Colin, R., Montilla, P., Peña, J., Jimena, I., Medina, F.J., and Tasset, I., Protective Effect of Nicotine on Oxidative and Cell Damage in Rats with Depression Induced by Olfactory Bulbectomy, Eur. J. Pharmacol., 2010, vol. 627, no. 1–3, pp. 115–118.

    Article  PubMed  Google Scholar 

  32. Amsterdam, J.D. and Shults, J., Efficacy and Mood Conversion Rate of Short-Term Fluoxetine Monotherapy of Bipolar II Major Depressive Episode, J. Clin. Psychopharmacol., 2010, vol. 30, no. 3. pp. 306–311.

    Article  PubMed  CAS  Google Scholar 

  33. Ciulla, L., Menezes, H.S., Bueno, B.B., Schuh, A., Alves, R.J., and Abegg, M.P., Antidepressant Behavioral Effects of Duloxetine and Fluoxetine in the Rat Forced Swimming Test, Acta Cir. Bras., 2007, vol. 22, no. 5, pp. 351–354.

    Article  PubMed  Google Scholar 

  34. Sidorenko, E.V., Metody matematicheskoi obrabotki v psikhologii (Methods of Mathematical Processing in Psychology), St. Petersburg, Rech, 2006.

    Google Scholar 

  35. Yunkerov, V.I. and Grigoriev, S.G., Matematikostatisticheskaya obrabotka dannykh meditsinskikh issledovanii (Mathematical-Statistical Processing of Data of Medical Studies), St. Petersburg, VmedA, 2002.

    Google Scholar 

  36. Zhelnikov, V., Kriptografiya ot papirusa do komp’-yu tera (Cryptography from Papyrus to Computer), Moscow, ABF, 1996.

    Google Scholar 

  37. Porsolt, R.D., Le Pichnon, M., and Jalfre, M., Depression: a New Animal Model Sensitive to Antidepressant Treatment, Nature, 1977. vol. 266. pp. 730–732.

    Article  PubMed  CAS  Google Scholar 

  38. Buresh, Ya., Bureshova, O., and Hewston, J.P., Metodiki i osnovnye eksperimenty po izucheniyu mozga i povedeniya (Procedures and the Main Experiments in Study of Brain and of Behavior), Moscow, 1991.

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Authors and Affiliations

  1. Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia

    K. N. Chichinadze, T. P. Damianidze, T. Ts. Matitaishvili, I. D. Labadze, I. N. Pantsulaya & M. M. Khananashvili

  2. Dzhavakhishvili Tbilisi State University, Tbilisi, Georgia

    K. N. Chichinadze

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  1. K. N. Chichinadze
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  2. T. P. Damianidze
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  3. T. Ts. Matitaishvili
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  4. I. D. Labadze
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  5. I. N. Pantsulaya
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  6. M. M. Khananashvili
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Correspondence to K. N. Chichinadze.

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Original Russian Text © K.N. Chichinadze, T.P. Damianidze, T.Ts. Matitaishvili, I.D. Labadze, I.N. Pantsulaya, M.M. Khananashvili, 2011, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2012, Vol. 48, No. 2, pp. 154–159.

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Chichinadze, K.N., Damianidze, T.P., Matitaishvili, T.T. et al. A new model of depression induced by psychogenic stress. J Evol Biochem Phys 48, 181–188 (2012). https://doi.org/10.1134/S0022093012020077

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  • DOI: https://doi.org/10.1134/S0022093012020077

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