Abstract
Innervation of chromaffin cells of paraganglia of the wall of mammalian large arterial vessels and heart (in rat, cat, and human) was studied by neuromorphological and immunohistochemical methods. There is established similarity in structure of specialized, “basket“-like nerve endings of the chromaffin cells (ChC) with pericellular nerve apparatuses of sympathetic and parasympathetic autonomic neurons. It is proposed to use immunohistochemical reaction for synaptophysin as method of selective detection of ChC of paraganglia and adrenal medulla. The conclusion is made that synaptophysin-positive terminals (SPPT) found on bodies of ChC and postganglionic neurons represent efferent, rather than afferent, synapses formed by myelinated axons of preganglionic fibers. It is suggested that ChC of paraganglia alongside with their characteristic endocrine function participate in complex mechanisms of chemoreceptor regulation of tissue homeostasis of mammalian blood vessels and heart.
Similar content being viewed by others
References
Nozdrachev, A.D. and Chumasov, E.I., Perifericheskaya nervnaya sistema. Struktura, razvitie, transplantatsiya i regeneratsiya (Peripheral Nervous System. Structure, Development, Transplantation, and Regeneration), St. Petersburg, 1999.
Smitten, N.A. and Shalyapina, V.G., Peripheral Neuroendocrine Chromaffin System of Vertebrates, Neiroendokrinologiya (Neuroendocrinology), Polenov, A.L., Ed., Leningrad, 1993, pp. 352–391.
Coupland, R.E., The Natural History of the Chromaffin Cell. Twenty-Five Years on the Beginning, Arch. Histol. Cytol., 1989, vol. 52, pp. 331–341.
Berthoud, H.-R. and Patterson, L.M., Innervation of Rat Abdominal Paraganglia by Calretinin-Like Immunoreactive Nerve Fibers, Neurosci. Lett., 1996, vol. 210, pp. 115–118.
Eyazaquierre, C., Chemical and Electric Transmission in Carotid Body Chemoreception, Biol. Res., 2005, vol. 38, pp. 341–345.
Ichikawa, H., Innervation of the Carotid Body: Immunohistochemical, Denervation, and Retrograde Tracing Studies, Microsc. Res. Tech., 2002, vol. 59, no. 3, pp. 188–195.
Bock, P., The Paraganglia, Berlin, 1982.
Calupca, M.A., Vizzard, M.A., and Parsons, R.L., Origin of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Immunoreactive Fibers Innervating Guinea Pig Parasympathetic Cardiac Ganglia, J. Comp. Neurol., 2000, vol. 423 no. 1, pp. 26–39.
Dun, N.J., Tang, H., Dun, D.L., Huang, R., Dun, E.C., and Wakade, A.R., Pituitary Adenylate Cyclase Activating Polypeptide-Immunoreactive Sensory Neurons Innervate Rat Adrenal Medulla, Brain Res., 1996, vol. 716, no. 1–2, pp. 11–21.
Kondo, H. and Yamamoto, M., Occurrence, Ontogeny, Ultrastructure and Some Plasticity of CGRP (Calcitonin Gene-Related Peptide)-Immunoreactive Nerves in the Carotid Body of Rats, Brain Res., 1988, vol. 473, no. 2, pp. 283–293.
Mascorro, J.A. and Yates, R.D., Innervation of Abdominal Paraganglia: an Ultrastructural Study, J. Morphology, 2005, vol. 142, no. 2, pp. 153–163.
Korzhevskii, D.E., Grigoriev, I.P., and Otellin, V.A., Use of Zinc Salt-Containing Dehydrating Fixatives in Neurohistological Studies, Morfologiya, 2006, vol. 129, no. 1, pp. 85–86.
Chumasov, E.I., Petrova, E.S., and Korzhevskii, D.E., Immunohistochemical Study of Innervation of the Rat Heart, Morfologiya, 2009, vol. 135, no. 2, pp. 33–37.
Chumasov, E.I., Atagimov, M.Z., Sokolov, V.I., and Seliverstova, V.G., Development of Chromaffin Tissue of the Adrenal Gland, Morfologiya, 2003, vol. 123, no. 3, pp. 68–73.
Scheuermann, D.W., Comparative Morphology, Cytochemistry and Innervation of Chromaffin Tissue in Vertebrates, J. Anat., 1993, vol. 183, pp. 327–342.
Hayashida, Y., Gonzales, C., and Kondo, H., The Arterial Chemoreceptors. Series: Advances in Experimental Medicine and Biology, Springer Science and Business, 2006, vol. 580, no. 14, pp. 1–362.
Murphy, S.M., McAllen, R., Campbell, G.D., Howe, P.R., and Anderson, C.R., Re-Establishment of Neurochemical Coding of Preganglionic Neurons Innervating Transplanted Targets, Neuroscience, 2003, vol. 117, pp. 347–360.
Partanen, M., Hervonen, A., and Rapoport, S.I., The Ultrastructure of Hypertrophied Paraganglia in Aged Rats, J. Anat., 1984, vol. 139, pp. 619–626.
Berthoud, H.-R., Kressel, M., and Neuhuber, W.L., Vagal Afferent Innervation of Rat Abdominal Paraganglia as Revealed by Anterograde DiI-Tracing and Confocal Microscopy, Acta Anat., 1995, vol. 152, no. 2, pp. 127–132.
Borghini, N., Dalmaz, Y., Peyrin, L., and Heym, C., Chemosensitivity, Plasticity and Functional Heterogeneity of Paraganglionic Cells in the Rat Coeliac-Superior Mesenteric Complex, Microsc. Res. Tech., 1994, vol. 29, no. 2, pp. 112–119.
Kummer, W. and Neuhuber, W.L., Vagal Paraganglia of the Rat, J. Electron Microsc. Tech., 1989, pp. 343–355.
Hansen, J.T., Ultrastructure of the Primate Carotid Body: a Morphometric Study of the Glomus Cell and Nerve Endings in the Monkey, J. Neurocytol., 1985, vol. 14, no. 1, pp. 13–32.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E. I. Chumasov, E. S. Petrova, D. E. Korzhevskii, 2011, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2011, Vol. 47, No. 4, pp. 325–331.
Rights and permissions
About this article
Cite this article
Chumasov, E.I., Petrova, E.S. & Korzhevskii, D.E. The immunomorphological analysis of innervation of paraganglian chromaffin cells of mammalian arteries and heart. J Evol Biochem Phys 47, 381–388 (2011). https://doi.org/10.1134/S0022093011040104
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0022093011040104