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Different effects of α- and γ-glycine on the aberrant activity of pyramidal neurons of hippocampal slices

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Abstract

Experiments in vitro on hippocampal slices of mouse have shown that solutions prepared from polymorphic modifications α- and γ-glycine have different effect on the aberrant activity of neurons. In the presence of α-glycine the excitability of these neurons decreased more slowly, prolonging its modulating effect on NMDA type glutamate receptors. This effect agrees with higher biological activity of α-polymorphic modifications (as compared with that of the α-form) that previously observed with respect to behavior of mice from the line with genetic diathesis to catalepsy, which were used as a biological model for investigation of some pathological behavior forms.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

    I. A. Malakhin, A. F. Achkasov, A. S. Ratushnyak, T. A. Zapara, A. L. Markel, E. V. Boldyreva & V. V. Boldyrev

  2. Institute of Design and Technology of Digital Techniques, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

    I. A. Malakhin, A. F. Achkasov, A. S. Ratushnyak, T. A. Zapara, A. L. Markel, E. V. Boldyreva & V. V. Boldyrev

  3. Novosibirsk State University, Novosibirsk, Russia

    I. A. Malakhin, A. F. Achkasov, A. S. Ratushnyak, T. A. Zapara, A. L. Markel, E. V. Boldyreva & V. V. Boldyrev

  4. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

    I. A. Malakhin, A. F. Achkasov, A. S. Ratushnyak, T. A. Zapara, A. L. Markel, E. V. Boldyreva & V. V. Boldyrev

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  1. I. A. Malakhin
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  2. A. F. Achkasov
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  3. A. S. Ratushnyak
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  4. T. A. Zapara
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  5. A. L. Markel
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  6. E. V. Boldyreva
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  7. V. V. Boldyrev
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Additional information

Original Russian Text © I.A. Malakhin, A.F. Achkasov, A.S. Ratushnyak, T.A. Zapara, A.L. Markel, E.V. Boldyreva, V.V. Boldyrev, 2012, published in Doklady Akademii Nauk, 2012, Vol. 444, No. 5, pp. 567–571.

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Malakhin, I.A., Achkasov, A.F., Ratushnyak, A.S. et al. Different effects of α- and γ-glycine on the aberrant activity of pyramidal neurons of hippocampal slices. Dokl Biol Sci 444, 157–161 (2012). https://doi.org/10.1134/S0012496612030179

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  • DOI: https://doi.org/10.1134/S0012496612030179

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