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Inhalation of High Doses of Gaseous Nitric Oxide in HIV Infection

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Abstract

The therapeutic effect of high-dose inhalation of nitrogen oxide gas (at a NO concentration of at least 1000 ppm) in two HIV-infected patients was demonstrated. Inhaled NO therapy led to a rapid decrease in viral load to an undetectable level, which persisted even after the period of analytical interruption of treatment. It was assumed that the relief of HIV infection was due to nitrosonium cations NO+ formed in the blood from neutral NO molecules. The subsequent conversion of NO+ cations in their reaction with hydroxyl anions into nitrite anions was prevented by the binding of NO+ cations with chlorine anions and the formation of nitrosochloride in the blood. The entry of this agent from the blood into cells and tissues provided the transfer of NO+ cations into them. The interaction of nitrosochloride with thiols could lead to the appearance of corresponding S-nitrosothiols in cells and tissues as NO donors.

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Funding

The work was done on an initiative basis. The cost of laboratory tests was paid for by the personal funds of the observed patients and the authors of the article.

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Authors and Affiliations

  1. Bauman Moscow State Technical University, 105005, Moscow, Russia

    A. V. Pekshev, A. B. Vagapov & N. A. Sharapov

  2. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    A. F. Vanin

Authors
  1. A. V. Pekshev
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  2. A. B. Vagapov
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  3. N. A. Sharapov
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  4. A. F. Vanin
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Corresponding author

Correspondence to A. F. Vanin.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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The authors of this work declare that they have no conflicts of interest.

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Translated by E. Puchkov

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Abbreviations: HIV, human immunodeficiency virus; ART, antiretroviral therapy; PCR, polymerase chain reaction.

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Pekshev, A.V., Vagapov, A.B., Sharapov, N.A. et al. Inhalation of High Doses of Gaseous Nitric Oxide in HIV Infection. BIOPHYSICS 68, 889–894 (2023). https://doi.org/10.1134/S0006350923050196

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  • DOI: https://doi.org/10.1134/S0006350923050196

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