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The antitumor effect of magnetic nanodisks and DNA aptamer conjugates

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

Here we describe a method of forming large arrays (up to 109 pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.

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References

  1. Giannaccini, M., Giannini, M., Calatayud, M.P., Goya, G.F., Cuschieri, A., Dente, L., and Raffa, V., Magnetic nanoparticles as intraocular drug delivery system to target retinal pigmented epithelium (RPE), Int. J. Mol. Sci., 2014, no. 15, pp. 1590–1605.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Wen, J., Jiang, S., Chen, Z., Zhao, W., Yi, Y., Yang, R., and Chen, B., Apoptosis selectively induced in Bel7402 cells by folic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field, Intern. J. Nanomed., 2014, vol. 9, pp. 2043–2050.

    Google Scholar 

  3. Chiang, C.-L. and Sung, C.-S., Purification of transfection-grade plasmid DNA from bacterial cells with superparamagnetic nanoparticles, J. Magn. Magn. Mater., 2006, no. 302, pp. 7–13.

    Article  CAS  Google Scholar 

  4. Pershina, A.G., Sazonov, A.E., and Filimonov, V.D., Interaction of magnetic nanoparticles and DNA molecules: creation of nanobiohybrid structures and their application, Usp. Khim., 2014, vol. 83, no. 4, pp. 299–322.

    Article  Google Scholar 

  5. Kim, D.-H., Rozhkova, E.A., Ulasov, I.V., Bader, S.D., Rajh, T., Lesniak, M.S., and Novosad, V., Biofunctionalized magnetic-vortex microdisks for targeted cancercell destruction, Nature Materials, 2010, vol. 9, pp. 165–171.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Rad’ko, S.P., Rakhmetova, S.Yu., Bodoev, N.V., and Archakov, A.I., Aptamers as promising affine reagents for clinical proteomics, Biomed. Khim., 2007, vol. 53, no. 1, pp. 5–24.

    PubMed  Google Scholar 

  7. Kolovskaya, O.S., Zamay, T.N., Zamay, A.S., Glazyrin, Y.E., Spivak, E.A., Zubkova, O.A., Kadkina, A.V., Erkaev, E.N., Zamay, G.S., Savitskaya, A.G., Trufanova, L.V., Petrova, L.L., and Berezovsky, M.V., DNA-aptamer/protein interaction as a cause of apoptosis and arrest of proliferation in Erlich ascites adenocarcinoma cells, Biochemistry, Suppl. Ser. A: Membrane and Cell Biol., 2014, vol. 8, no. 1, pp. 60–72.

    Article  Google Scholar 

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Authors and Affiliations

  1. Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia

    P. D. Kim, S. S. Zamay, O. S. Kolovskaya, G. S. Zamay, E. A. Spivak, A. V. Dubinina, A. V. Komarov, V. V. Denisenko, M. A. Komarova, A. E. Sokolov, A. A. Narodov & A. S. Zamay

  2. Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia

    S. S. Zamay, T. N. Zamay, O. S. Kolovskaya, G. S. Zamay, A. V. Dubinina, M. A. Komarova, A. A. Narodov & A. S. Zamay

  3. Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia

    T. N. Zamay, R. Yu. Rudenko, A. V. Dubinina, A. V. Komarov & V. V. Denisenko

  4. Institute of Chemistry and Chemical Technology, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russia

    A. S. Zamay

  5. Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 13, Novosibirsk, 630090, Russia

    P. D. Kim, V. Ya. Princ, V. A. Seleznev & A. I. Komonov

  6. Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia

    S. S. Zamay, R. Yu. Rudenko & A. E. Sokolov

  7. Astaf’ev Krasnoyarsk State Pedagogical University, ul. A. Lebedevoi 89, Krasnoyarsk, 660049, Russia

    V. S. Prokopenko & V. P. Zjivaev

Authors
  1. P. D. Kim
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  2. S. S. Zamay
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  3. T. N. Zamay
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  4. V. S. Prokopenko
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  5. O. S. Kolovskaya
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  6. G. S. Zamay
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  7. V. Ya. Princ
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  8. V. A. Seleznev
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  9. A. I. Komonov
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  10. E. A. Spivak
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  11. R. Yu. Rudenko
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  12. A. V. Dubinina
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  13. A. V. Komarov
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  14. V. V. Denisenko
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  15. M. A. Komarova
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  16. A. E. Sokolov
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  17. A. A. Narodov
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  18. V. P. Zjivaev
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  19. A. S. Zamay
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Corresponding author

Correspondence to T. N. Zamay.

Additional information

Original Russian Text © P.D. Kim, S.S. Zamay, T.N. Zamay, V.S. Prokopenko, O.S. Kolovskaya, G.S. Zamay, V.Ya. Princ, V.A. Seleznev, A.I. Komonov, E.A. Spivak, R.Yu. Rudenko, A.V. Dubinina, A.V. Komarov, V.V. Denisenko, M.A. Komarova, A.E. Sokolov, A.A. Narodov, V.P. Zjivaev, A.S. Zamay, 2016, published in Doklady Akademii Nauk, 2016, Vol. 466, No. 5, pp. 616–619.

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Kim, P.D., Zamay, S.S., Zamay, T.N. et al. The antitumor effect of magnetic nanodisks and DNA aptamer conjugates. Dokl Biochem Biophys 466, 66–69 (2016). https://doi.org/10.1134/S1607672916010154

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  • DOI: https://doi.org/10.1134/S1607672916010154

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