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Synthesis of Phosphoramidates Based on Aminopyridines

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Abstract

Reaction of diethyl chlorophosphate with aminopyridines furnished a series of new diethyl phosphoramidates. The effect on the reactivity of substituents in the pyridine ring was studied. Structure of the obtained compound was characterized by 1H, 13C, 31P, 2D HMBC 1H–15N NMR spectroscopy, mass-spectrometry, and single crystal X-ray diffraction analysis.

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Funding

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (project no. 0785.00.X6019) using the equipment of the Engineering Center of the St. Petersburg State Technological Institute and the Resource Centers “X-ray diffraction methods of research” and “Methods of analysis of the composition of matter” of the Science Park of St. Petersburg State University.

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    A. S. Krylov, Yu. L. Piterskaya, D. Yu. Voronina & A. V. Dogadina

  2. St. Petersburg State University, 199034, St. Petersburg, Russia

    V. V. Gurzhiy

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  1. A. S. Krylov
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Correspondence to A. S. Krylov.

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Krylov, A.S., Piterskaya, Y.L., Gurzhiy, V.V. et al. Synthesis of Phosphoramidates Based on Aminopyridines. Russ J Gen Chem 92, 1912–1918 (2022). https://doi.org/10.1134/S1070363222100061

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