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The influence of the recombinant human heat shock protein Hsp70 on the biochemical properties of blood during endotoxic shock simulation in rats

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Abstract

The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous injection in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coli endotoxin on the rats’ bodies and significantly increased the survival of the animals during the experiment.

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Abbreviations

HSP70:

heat shock protein with a molecular mass of 70 kDa

hrHSP70 and bHSP70:

human recombinant and bovine HSP70

LPS:

lipopolysaccharide

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Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences, pr. Nauki 6, Pushchino, Moscow oblast, 142290, Russia

    V. F. Ostrov, G. A. Slashcheva, T. Yu. Zharmukhamedova & A. N. Murashev

  2. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984, Russia

    D. G. Garbuz & M. B. Evgen’ev

Authors
  1. V. F. Ostrov
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  2. G. A. Slashcheva
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  3. T. Yu. Zharmukhamedova
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  4. D. G. Garbuz
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  5. M. B. Evgen’ev
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  6. A. N. Murashev
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Corresponding author

Correspondence to V. F. Ostrov.

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Original Russian Text © V.F. Ostrov, G.A. Slashcheva, T.Yu. Zharmukhamedova, D.G. Garbuz, M.B. Evgen’ev, A.N. Murashev, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 3, pp. 337–342.

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Ostrov, V.F., Slashcheva, G.A., Zharmukhamedova, T.Y. et al. The influence of the recombinant human heat shock protein Hsp70 on the biochemical properties of blood during endotoxic shock simulation in rats. Russ J Bioorg Chem 36, 310–314 (2010). https://doi.org/10.1134/S1068162010030052

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  • DOI: https://doi.org/10.1134/S1068162010030052

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