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Extracellular Matrix in the Regulation of Stem Cell Differentiation

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Abstract

Extracellular matrix (ECM) proteins fill the space between cells in multicellular organisms, contributing to the structure of organs and tissues. The mechanical properties of ECM are well studied. At present, the role of individual ECM components and the three-dimensional tissue-specific matrices in the regulation of cell functional activity, proliferation, migration, acquisition of a specialized phenotype and its maintenance is intensively studied. In this review, we described main ECM structural proteins, enzymes, and extracellular vesicles and present the data on the participation of ECM components in the regulation of stem cell differentiation and self-maintenance, as well as approaches to the modeling of stem cells microenvironment using decellularized ECM.

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Abbreviations

(d)ECM:

(decellularized) extracellular matrix

MMP:

matrix metalloproteinase

MSC:

mesenchymal stromal cell

NGN3:

neurogenin 3

PDX1:

pancreatic and duodenal homeobox 1

TAZ:

transcriptional coactivator with PDZ-binding motif

TGF-β:

transforming growth factor beta

YAP:

Yes-associated protein

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Authors and Affiliations

  1. Institute for Regenerative Medicine, Medical Research and Education Center, Lomonosov Moscow State University, 119991, Moscow, Russia

    E. S. Novoseletskaya, O. A. Grigorieva & A. Yu. Efimenko

  2. Lomonosov Moscow State University, Faculty of Medicine, 119991, Moscow, Russia

    E. S. Novoseletskaya, A. Yu. Efimenko & N. I. Kalinina

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  1. E. S. Novoseletskaya
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  2. O. A. Grigorieva
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  3. A. Yu. Efimenko
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  4. N. I. Kalinina
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Correspondence to A. Yu. Efimenko.

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Published in Russian in Biokhimiya, 2019, Vol. 84, No. 3, pp. 343–353.

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Novoseletskaya, E.S., Grigorieva, O.A., Efimenko, A.Y. et al. Extracellular Matrix in the Regulation of Stem Cell Differentiation. Biochemistry Moscow 84, 232–240 (2019). https://doi.org/10.1134/S0006297919030052

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