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Proteins involved in binding and cellular uptake of nucleic acids

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Abstract

The study of mechanisms of nucleic acid transport across the cell membrane is valuable both for understanding the biological function of extracellular nucleic acids and the practical use of nucleic acids in gene therapy. It has been clearly demonstrated that cell surface proteins are necessary for transport of nucleic acids into cells. A large amount of data has now been accumulated about the proteins that participate in nucleic acid transport. The methods for revealing and dentification of these proteins, possible mechanisms of protein-mediated transport of nucleic acids, and cellular functions of these proteins are described.

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Authors and Affiliations

  1. Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, ul. Akademika Timakova 2, 630117, Novosibirsk, Russia

    B. P. Chelobanov

  2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, pr. Akademika Lavrentieva 8, 630090, Novosibirsk, Russia

    P. P. Laktionov & V. V. Vlasov

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  1. B. P. Chelobanov
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  2. P. P. Laktionov
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  3. V. V. Vlasov
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Correspondence to B. P. Chelobanov.

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Original Russian Text © B. P. Chelobanov, P. P. Laktionov, V. V. Vlasov, 2006, published in Biokhimiya, 2006, Vol. 71, No. 6, pp. 725–741.

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Chelobanov, B.P., Laktionov, P.P. & Vlasov, V.V. Proteins involved in binding and cellular uptake of nucleic acids. Biochemistry (Moscow) 71, 583–596 (2006). https://doi.org/10.1134/S0006297906060010

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