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The purine metabolism of human erythrocytes

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Abstract

This review summarizes currently available information about a crucial part of erythrocyte metabolism, that is, purine nucleotide conversions and their relationships with other conversion pathways. We describe the cellular resynthesis, interconversion, and degradation of purine compounds, and also the regulatory mechanisms in the conversion pathways. We also mention purine metabolism disorders and their clinical consequences. The literature is fragmentary because studies have concentrated only on selected aspects of purine metabolism; hence the need for a synthetic approach.

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Abbreviations

ADA:

adenosine deaminase (EC 3.5.4.4)

Ade:

adenine

Ado:

adenosine

AdoK:

adenosine kinase (EC 2.7.1.20)

AEC:

adenylate energy charge

AK:

adenylate kinase (EC 2.7.4.3)

AMP-D:

AMP deaminase (EC 3.5.4.6)

APRT:

adenine phosphoribosyltransferase (EC 2.4.2.7)

2,3-BPG:

2,3-bisphosphoglycerate

cN-I:

cytosolic AMP-specific 5′-nucleotidase (EC 3.2.3.5)

cN-II:

cytosolic IMP-and GMP-specific 5′-nucleotidase (EC 3.2.3.5)

GEC:

guanylate energy charge

Gua:

guanine

Guo:

guanosine

GuoK:

guanosine kinase (EC 2.7.1.73)

HGPRT:

hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)

HK:

hexokinase (EC 2.7.1.1)

Hyp:

hypoxanthine

Ino:

inosine

InoK:

inosine kinase (EC 2.7.1.73)

MTA:

methylthioadenosine

5′-NT:

5′-nucleotidase (EC 3.1.3.5)

PFK:

phosphofructokinase (EC 2.7.1.11)

PGK:

phosphoglycerate kinase (EC 2.7.2.3)

Pi :

orthophosphate

PPi :

pyrophosphate

PK:

pyruvate kinase (EC 2.7.1.40)

PNP:

purine nucleoside phosphorylase (EC 2.4.2.1)

PRPP:

5′-phosphoribosyl 1-pyrophosphate

Rib-1-P:

ribose-1-phosphate

Rib-5-P:

ribose-5-phosphate

SAH:

S-adenosylhomocysteine

SAHH:

S-adenosylhomocysteine hydrolase (EC 3.3.1.1)

SAM:

S-adenosylmethionine

TA:

transaldolase (EC 2.2.1.2)

TAN:

total adenine nucleotides

TGN:

total guanine nucleotides

TK:

transketolase (EC 2.2.1.1)

XMP:

xanthosine-5′-monophosphate

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Natural Sciences, University of Szczecin, 3a Felczaka, 71-412, Szczecin, Poland

    W. Dudzinska, A. J. Hlynczak & E. Skotnicka

  2. Department of Animal Physiology, Faculty of Natural Sciences, University of Szczecin, Piastow 40 B Av., 70-065, Szczecin, Poland

    M. Suska

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  1. W. Dudzinska
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  2. A. J. Hlynczak
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  3. E. Skotnicka
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  4. M. Suska
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Correspondence to W. Dudzinska.

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Published in Russian in Biokhimiya, 2006, Vol. 71, No. 5, pp. 581–591.

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Dudzinska, W., Hlynczak, A.J., Skotnicka, E. et al. The purine metabolism of human erythrocytes. Biochemistry (Moscow) 71, 467–475 (2006). https://doi.org/10.1134/S0006297906050014

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  • DOI: https://doi.org/10.1134/S0006297906050014

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