Abstract
A polymeric compound of poly(N-vinyl succinamic acid) and poly(vinyl alcohol) is obtained by conducting the polymerization of N-vinyl succinimide and reactions in the chains of its polymer in the presence of poly(vinyl alcohol). The possibility for the intermolecular acetalization and structuring of the (co)polymers of vinyl alcohol containing ionic units of N-vinyl succinamic acid with the use of glutaric aldehyde is determined. The swelling and moisture absorption of the structured (co)polymers and their ability to sorb low-molecular-weight biologically active substances with their prolonged release is studied.
Similar content being viewed by others
REFERENCES
L. I. Shal’nova, N. A. Lavrov, and A. F. Nikolaev, “The possibility of predicting prolongation of the pharmacological action of biologically active polymeri substances,” Int. Polym. Sci. Technol. 39 (11), 21–27 (2012).
M. V. Semenova, S. V. Osadchenko, Ya. O. Mezhuev, M. I. Shtil’man, and I. N. Semenova, “Synthesis of hemocompatible materials based on branched polyvinyl alcohol,” Russ. J. Appl. Chem. 89 (8), 1286–1291 (2016).
A. A. Artyukhov, A. A. Morgacheva, A. N. Kuskov, and M. I. Shtil’man, “Biodegradable macroporous polymeric hydrogels based on polyvinyl alcohol and 2‑hydroxyethyl starch,” Vse Mater., Entsikl. Sprav., No. 4, 2–8 (2016).
A. A. Artyukhov, A. S. Golunova, L. I. Pashkova, et al., “Macroporous polymeric hydrogels of polyvinyl alcohol containing amino groups,” Plast. Massy, No. 4, 15–21 (2010).
O. A. Legon’kova, V. G. Vasil’ev, and L. Yu. Asanova, “Methods for assessing the performance properties of polymeric dressing tools,” Vse Mater., Entsikl. Sprav., No. 8, 10–14 (2015).
A. Ya. Sorokin, V. A. Kuznetsova, M. I. Kuzin, et al., RF Inventor’s Certificate No. 1705304, Byull. Izobret., No. 2 (1992).
N. A. Lavrov and L. I. Shal’nova, “Specific features of preparation of polymer carriers of physiologically active substances based on N-vinylsuccinimide derivatives,” Polym. Sci., Ser. D 5 (3), 202–204 (2012).
N. A. Lavrov, “Theoretical and practical aspects of the synthesis of medical polymers based on N-vinylsuccinimide in aqueous media,” Int. Polym. Sci. Technol. 39 (1), 47–60 (2012).
M. D. Mashkovskii, Pharmaceuticals, 16th ed. (Novaya volna, Izd. Umerenkov, Moscow, 2017) [in Russian].
ACKNOWLEDGMENTS
This work was performed within the framework of a state order from the Ministry of Education and Science of the Russian Federation, 11.5362.2017/8.9.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by E. Boltukhina
Rights and permissions
About this article
Cite this article
Shal’nova, L.I., Lavrov, N.A. Gel-Forming Compounds on the Basis of Derivatives of (Co)Polymers of N-Vinyl Succinimide and Poly(Vinyl Alcohol) as Biofunctional Sorbents. Polym. Sci. Ser. D 12, 96–99 (2019). https://doi.org/10.1134/S1995421219010179
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1995421219010179