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Amphiphilic polymers in photodynamic therapy

  • Chemical Physics of Polymer Materials
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Russian Journal of Physical Chemistry B Aims and scope Submit manuscript

Abstract

It is shown that some amphiphilic polymers (AP), including, polyvinylpyrrolidone (PVP), which exhibit no their own photochemical activity, can increase the activity of porphyrin photosensitizers (PPS), the most effective and nontoxic types of dyes for photodynamic action on tumor cells. It is also shown that, under the model conditions of tryptophan photooxidation, addition of amphiphilic polymers increases the activity of carborane-substituted tetra(fluorophenyl)porphyrins, Photoditazine, and dimegin. According to NMR and fluorescence spectroscopy data, this phenomenon, known as polymer effect, is probably associated with the formation of AP-PPS complexes, a factor that prevents the aggregation of PPS, normally occurring in aqueous solutions, thereby enhancing the photosensitizing activity of PPS.

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Authors and Affiliations

  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. B. Solov’eva, N. A. Aksenova & N. N. Glagolev

  2. Moscow State University, Moscow, Russia

    N. S. Melik-Nubarov

  3. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia

    A. V. Ivanov

  4. Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia

    V. I. Volkov & A. V. Chernyak

Authors
  1. A. B. Solov’eva
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  2. N. A. Aksenova
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  3. N. N. Glagolev
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  4. N. S. Melik-Nubarov
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  5. A. V. Ivanov
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  6. V. I. Volkov
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  7. A. V. Chernyak
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Corresponding author

Correspondence to N. A. Aksenova.

Additional information

Original Russian Text © A.B. Solov’eva, N.A. Aksenova, N.N. Glagolev, N.S. Melik-Nubarov, A. V. Ivanov, V.I. Volkov, A.V. Chernyak, 2012, published in Khimicheskaya Fizika, 2012, Vol. 31, No. 6, pp. 72–80.

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Solov’eva, A.B., Aksenova, N.A., Glagolev, N.N. et al. Amphiphilic polymers in photodynamic therapy. Russ. J. Phys. Chem. B 6, 433–440 (2012). https://doi.org/10.1134/S1990793112060061

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  • DOI: https://doi.org/10.1134/S1990793112060061

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