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Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation

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Abstract

Carnosine is an endogenous dipeptide with antiproliferative properties. Here we show that carnosine selectively inhibits proliferation of human glioblastoma cells (U-118-MG) compared to breast (MB231) and head and neck carcinoma (FaDu and Cal27) cells. Carnosine-induced inhibition of U-118-MG proliferation is associated with a significant: decrease in cellular reactive oxygen species levels, increase in manganese superoxide dismutase (MnSOD) and increase in cyclin B1 expression resulting in G2-block. We conclude that the antiproliferative property of carnosine is due to its ability to enhance MnSOD and cyclin B1 expression. These results will be of significance to the potential application of carnosine in brain cancer therapy.

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Authors and Affiliations

  1. Laboratory of Clinical and Experimental Neurochemistry, Neurology Research Center, Russian Academy of Medical Sciences, Volokolamskoe sh. 80, Moscow, 125367, Russia

    Y. S. Rybakova & T. N. Fedorova

  2. Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA

    A. L. Kalen, J. C. Eckers, P. C. Goswami & E. H. Sarsour

Authors
  1. Y. S. Rybakova
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  2. A. L. Kalen
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  3. J. C. Eckers
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  4. T. N. Fedorova
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  5. P. C. Goswami
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  6. E. H. Sarsour
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Corresponding author

Correspondence to Y. S. Rybakova.

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Original Russian Text © Y.S. Rybakova, A.L. Kalen, J.C. Eckers, T.N. Fedorova, P.C. Goswami, E.H. Sarsour, 2015, published in Biomeditsinskaya Khimiya.

The article was translated by the author (Y.S. Rybakova).

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Rybakova, Y.S., Kalen, A.L., Eckers, J.C. et al. Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation. Biochem. Moscow Suppl. Ser. B 9, 63–71 (2015). https://doi.org/10.1134/S1990750815010096

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  • DOI: https://doi.org/10.1134/S1990750815010096

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