Abstract
In the study of the sequence of depolarization of the atrial subepicardium of rats in the short-term alcohol consumption model (the “Holiday heart” syndrome), the localization of the sources of atrial arrhythmias was determined for the first time. The difference in the excitation of the right and left atria was discovered: the right atrium is activated anterogradely from the sinoatrial node, whereas the left atrium is activated retrogradely from the ectopic focus located in the left auricular appendage.
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REFERENCES
Liang, Y., Mente, A., Yusuf, S., et al., Alcohol consumption and the risk of incident atrial fibrillation among people with cardiovascular disease, C.M.A.J., 2012, vol. 184, no. 16, pp. E857–E866. https://doi.org/10.1503/cmaj.120412
Voskoboinik, A., Prabhu, S., Ling, L.H., et al., Alcohol and atrial fibrillation: a sobering review, J. Am. Coll. Cardiol., 2016, vol. 68, no. 23, pp. 2567–2576. https://doi.org/10.1016/j.jacc.2016.08.074
Ettinger, P.O., Wu, C.F., De La Cruz, C., Jr., et al., Arrhythmias and the “holiday heart:” alcohol-associated cardiac rhythm disorders, Am. Heart J., 1978, vol. 95, no. 5, pp. 555–562. https://doi.org/10.1016/0002-8703(78)90296-X
Tonelo, D., Providencia, R., and Goncalves, L., Holiday heart syndrome revisited after 34 years, Arq. Bras. Cardiol., 2013, vol. 101, no. 2, pp. 183–189. https://doi.org/10.5935/abc.20130153
Brunner, S., Herbel, R., Drobesch, C., et al., Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the, Munich: Octoberfest: results from the Munich Beer Related Electrocardiogram Workup study (MunichBREW), Eur. Heart J., 2017, vol. 38, no. 27, pp. 2100–2106. https://doi.org/10.1093/eurheartj/ehx156
Carey, M.G., Al-Zaiti, S.S., Kozik, T.M., et al., Holiday heart syndrome, Am. J. Crit. Care, 2014, vol. 23, no. 2, pp. 171–172. https://doi.org/10.4037/ajcc2014800
Rosenberg, M.A. and Mukamal, K.J., The estimated risk of atrial fibrillation related to alcohol consumption, J. Atr. Fibrillation, 2012, vol. 5, no. 1, p. 424. https://doi.org/10.4022/jafib.424
Roshchevskii, M.P., Arteeva, N.V., Kolomeets, N.L., et al., KARDIOINFORM system for visualization and analysis of the electric field of the heart, Med. Akad. Zh., 2005, no. 5, pp. 74–79.
Kryzhanovskii, S.A., Kolik, L.G., Tsorin, I.B., et al., On the potential use of echocardiography for assessing the formation of alcoholic cardiomyopathy, Hum. Physiol., 2014, vol. 40, no. 1, pp. 105–110. http://dx.doi.org/10.7868/S013116461401010X
Smirnova, S.L., Roshchevskaya, I.M., Roshchevsky, M.P., et al., Atria depolarization in rats with alcoholic cardiomyopathy, Dokl. Biol. Sci., 2018, vol. 479, pp. 41–43. https://doi.org/10.7868/S086956521807023X
Cheung, D.W., Electrical activity of the pulmonary vein and its interaction with the right atrium in the guinea-pig, J. Physiol., 1980, vol. 314, pp. 445–456. https://doi.org/10.1113/jphysiol.1981.sp013718
Chen, Y.J. and Chen, S.A., Electrophysiology of pulmonary veins, J. Cardiovasc. Electrophysiol., 2006, vol. 17, pp. 220–224. https://doi.org/10.1111/j.1540-8167.2005.00317.x
Scheinman, M.M. and Morady, F., Nonpharmacological approaches to atrial fibrillation, Circulation, 2001, vol. 103, pp. 2120–2125. https://doi.org/10.1161/01.CIR.103.16.2120
Batalov, R.E., Antonchenko, I.V., and Popov S.V., Pathophysiological prerequisites for catheter treatment of atrial fibrillation, Vestn. Aritmol., 2010, no. 60, pp. 70–74.
Murtaza, G., Yarlagadda, B., Akella, K., et al., Role of the left atrial appendage in systemic homeostasis, Card. Electrophysiol. Clin., 2020, vol. 12, pp. 21–28. https://doi.org/10.1016/j.ccep.2019.11.004
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Statement on the welfare of animals. The experiments on animals were approved by the Commission on Biomedical Ethics of the Zakusov Research Institute of Pharmacology (protocol no. 4 dated February 28, 2018) in accordance with the rules of the European Convention ETS 123.
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Smirnova, S.L., Roshchevskaya, I.M., Stolyaruk, V.N. et al. Depolarization of the Rat Atria in Experimental Simulation of the Holiday Heart Syndrome. Dokl Biochem Biophys 495, 304–306 (2020). https://doi.org/10.1134/S1607672920060149
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DOI: https://doi.org/10.1134/S1607672920060149