Skip to main content
SpringerLink
Log in

Synthesis of methyl 7-aryl-6-(2-thenoyl)-4,7-dihydro-tetrazolo[1,5-a]pyrimidine-5-carboxylates and their reaction with hydrazine hydrate

  • Published:
Russian Journal of Organic Chemistry Aims and scope Submit manuscript

Abstract

Fusion of methyl 4-(2-thienyl)-2,4-dioxobutanoate with 1H-tetrazol-5-amine monohydrate and aromatic aldehyde gave methyl 7-aryl-6-(2-thenoyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates which reacted with an equimolar amount of hydrazine hydrate at 180–190°C under solvent-free conditions to produce 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo[1′,5′: 1,2]pyrimido[4,5-d]pyridazin-5(6H)-ones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gein, V.L., Gein, L.F., Tsyplyakova, E.P., and Rozova, E.A., Russ. J. Org. Chem., 2003, vol. 39, p. 753.

    Article  CAS  Google Scholar 

  2. Gein, V.L., Gein, L.F., and Tsyplyakova, E.P., Khim. Geterotsikl. Soedin., 2003, p. 949.

  3. Gein, V.L., Gein, L.F., Tsyplyakova, E.P., and Panova, O.S., Russ. J. Org. Chem., 2007, vol. 43, p. 1382.

    Article  CAS  Google Scholar 

  4. Gein, V.L., Mishunin, V.V., Tsyplyakova, E.P., Vinokurova, O.V., and Vakhrin, M.I., Khim-Farm. Zh., 2009, vol. 43, no. 12, p. 46.

    Google Scholar 

  5. Sheldrick, G.M., Acta Crystallogr., Sect. A, 2008, vol. 64, p. 112.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Federal Health and Social Development Agency, ul. Lenina 48, Perm, 614990, Russia

    V. L. Gein, V. V. Mishunin & M. I. Vakhrin

  2. Perm Institute (Branch), Russian State University of Trade and Economics, bul’var Gagarina 57, Perm, 614070, Russia

    E. P. Tsyplyakova

  3. Postovskii Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, ul. S. Kovalevskoi 20, Yekaterinburg, 620219, Russia

    P. A. Slepukhin

Authors
  1. V. L. Gein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. V. Mishunin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. P. Tsyplyakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. I. Vakhrin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. A. Slepukhin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. L. Gein.

Additional information

Original Russian Text © V.L. Gein, V.V. Mishunin, E.P. Tsyplyakova, M.I. Vakhrin, P.A. Slepukhin, 2011, published in Zhurnal Organicheskoi Khimii, 2011, Vol. 47, No. 7, pp. 1060–1064.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gein, V.L., Mishunin, V.V., Tsyplyakova, E.P. et al. Synthesis of methyl 7-aryl-6-(2-thenoyl)-4,7-dihydro-tetrazolo[1,5-a]pyrimidine-5-carboxylates and their reaction with hydrazine hydrate. Russ J Org Chem 47, 1077–1082 (2011). https://doi.org/10.1134/S1070428011070189

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070428011070189

Keywords

Search

Navigation