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Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity

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Abstract

The synthetically convenient method of preparation of unexplored phosphoryl analogs of salicylic acid (2-hydroxyphenylphosphonic and 2-hydroxyphenylphosphinic acids) has been developed for the search of novel nonsteroidal anti-inflammatory drugs. It has been shown that 2-hydroxyphenylphosphinic acid is a lowtoxic compound (LD50 3500 mg/kg) exhibiting analgesic activity significantly higher than both 2-hydroxyphenylphosphonic acid and the reference compound (sodium metamizole).

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnii pr. 1, Chernogolovka, 142432, Russia

    V. E. Baulin, I. P. Kalashnikova, Yu. B. Vikharev & E. A. Vikhareva

  2. Frumkin Institute of Physical Chemistry and Electrochemistry, Moscow, Russia

    V. E. Baulin, D. V. Baulin & A. Yu. Tsivadze

Authors
  1. V. E. Baulin
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  2. I. P. Kalashnikova
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  3. Yu. B. Vikharev
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  4. E. A. Vikhareva
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  5. D. V. Baulin
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  6. A. Yu. Tsivadze
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Correspondence to V. E. Baulin.

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Dedicated to the 110th anniversary of M.I. Kabachnik’s birth

Original Russian Text © V.E. Baulin, I.P. Kalashnikova, Yu.B. Vikharev, E.A. Vikhareva, D.V. Baulin, A.Yu. Tsivadze, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 9, pp. 1438–1444.

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Baulin, V.E., Kalashnikova, I.P., Vikharev, Y.B. et al. Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity. Russ J Gen Chem 88, 1786–1791 (2018). https://doi.org/10.1134/S1070363218090049

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  • DOI: https://doi.org/10.1134/S1070363218090049

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