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Oxidation of 5-hydroxy-6-methyluracil with molecular oxygen in the presence of copper(II) chloride in aqueous solution

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Abstract

Oxidation of 5-hydroxy-6-methyluracil with molecular oxygen in the presence of copper(II) chloride involves formation of a 2 : 1 complex with copper(II). The rates of consumption of initial 5-hydroxy-6-methyluracil and oxygen were determined in the temperature range from 40 to 80°C. A probable reaction mechanism implies fixation and activation of molecular oxygen on the copper(II) complex with 5-hydroxy-6-methyluracil with formation of active oxygen species that are responsible for hydroxylation of the double C5=C6 bond in the uracil molecule.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Bashkortostan, Russia

    T. R. Nugumanov, A. V. Antipin, S. A. Grabovskii, N. N. Kabal’nova & Yu. I. Murinov

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  1. T. R. Nugumanov
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  2. A. V. Antipin
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  3. S. A. Grabovskii
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  4. N. N. Kabal’nova
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  5. Yu. I. Murinov
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Correspondence to Yu. I. Murinov.

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Original Russian Text © T.R. Nugumanov, A.V. Antipin, S.A. Grabovskii, N.N. Kabal’nova, Yu.I. Murinov, 2011, published in Zhurnal Obshchei Khimii, 2011, Vol. 81, No. 7, pp. 1195–1198.

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Nugumanov, T.R., Antipin, A.V., Grabovskii, S.A. et al. Oxidation of 5-hydroxy-6-methyluracil with molecular oxygen in the presence of copper(II) chloride in aqueous solution. Russ J Gen Chem 81, 1543–1546 (2011). https://doi.org/10.1134/S107036321107022X

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  • DOI: https://doi.org/10.1134/S107036321107022X

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