Abstract
Sulfadimidine, a bacteriostatic drug blocking folic acid synthesis, was labeled with 99mTc producing a yield of about 90%. The optimum conditions required to obtain 90% yield of the 99mTc complex were as follows: 500 μg of sulfadimidine, 100 μg of SnCl2·2H2O, 5 min, room temperature (25 ± 1°C), pH 4 (0.5 M citrate buffer). The radiochemical purity of the labeled compound was determined using paper and thin-layer chromatography. Biodistribution study in normal mice showed high uptake of the 99mTc complex in stomach and intestine. The ratio of the uptake of the 99mTc complex in muscles infected with E. coli to that in normal mice was about 2, 1.5 and 1.4 at 15, 90, and 180 min post injection, respectively, whereas for the muscles inflamed with heat-killed E. coli or sterile turpentine oil the difference from the normal muscles was insignificant.
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References
Bormans, G., Cleynhens, B., Adriaens, P., et al., J. Label. Compd. Radiopharm., 1993, vol. 33, pp. 1065–1078.
Serafini, A.N., J. Nucl. Med., 1993, vol. 34, suppl. 3, pp. 533–536.
Huston, J.S., George, A.J.T., Adams, G.P., et al., Q. J. Nucl. Med., 1996, vol. 40, pp. 320–333.
Delaloye, A.B. and Delaloye, B., Eur. J. Nucl. Med., 1995, vol. 22, pp. 139–147.
Behr, T.M. and Goldenberg, D.M., J. Nucl. Med., 1996, vol. 37, pp. 834–836.
Lister-James, J., Moyer, B.R., and Dean, R.T., Q. J. Nucl. Med., 1996, vol. 40, pp. 221–233.
Jones, A.G., Orvig, C., Trop, H.S., et al., J. Nucl. Med., 1980, vol. 21, pp. 279–281.
Kung, H.F., Guo, Y.Z., Yu, C.C., et al., J. Med. Chem., 1989, vol. 32, pp. 433–437.
Davison, A., Jones, A.G., Orvig, C., and Sohn, M., Inorg. Chem., 1981, vol. 20, pp. 1629–1632.
Pirmettis, I.C., Papadopoulos, M.S., Mastrostamatis, S.G., et al., Inorg. Chem., 1996, vol. 35, pp. 1685–1691.
Edwards, D.S., Liu, S., Poirier, M.J., et al., Inorg. Chem., 1994, vol. 33, pp. 5607–5609.
Moustapha, M.E., Motaleb, M.A., and Ibrahim, I.T., J. Radioanal. Nucl. Chem., 2011, vol. 287, pp. 35–40.
Ibrahim, I.T., Motaleb, M.A., and Attallah, K.M., J. Radioanal. Nucl. Chem., 2010, vol. 285, pp. 431–436.
Talaat, H.M., Ibrahim, I.T., and Attallah, K.M., Isot. Radiat. Res., 2009, vol. 41, no. 2, pp. 557–568.
Rao, T.N., Adhikesavalu, D., Camerman, A., and Fritzberg, A.R., J. Am. Chem. Soc., 1990, vol. 112, pp. 5798–5804.
Eshima, D., Taylor, A.J., Fritzberg, A.R., et al., J. Nucl. Med., 1987, vol. 28, pp. 1180–1186.
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Published in Russian in Radiokhimiya, 2014, Vol. 56, No. 1, pp. 64–67.
The text was submitted by the authors in English.
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Amin, A.M., Ibrahim, I.T., Attallah, K.M. et al. 99mTc-sulfadimidine as a potential radioligand for differentiation between septic and aseptic inflammations. Radiochemistry 56, 72–75 (2014). https://doi.org/10.1134/S1066362214010147
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DOI: https://doi.org/10.1134/S1066362214010147