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Matrix effect and methods for its elimination in bioanalytical methods using chromatography-mass spectrometry

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Abstract

The causes of the occurrence of matrix effect in bioanalytical methods using chromatography-mass spectrometry have been discussed. The comparative evaluation of the most frequently used methods for the reduction and elimination of matrix effects by the selection of an internal standard, various versions of sample preparation of biological samples for analysis, and the optimization of chromatographic and mass-spectrometric parameters has been performed. International requirements to the determination of the matrix effect in the validation of bioanalytical methods have been considered.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskii pr. 26, Petrodvorets, St. Petersburg, 198504, Russia

    D. V. Yaroshenko & L. A. Kartsova

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  1. D. V. Yaroshenko
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  2. L. A. Kartsova
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Original Russian Text © D.V. Yaroshenko, L.A. Kartsova, 2014, published in Zhurnal Analiticheskoi Khimii, 2014, Vol. 69, No. 4, pp. 351–358.

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Yaroshenko, D.V., Kartsova, L.A. Matrix effect and methods for its elimination in bioanalytical methods using chromatography-mass spectrometry. J Anal Chem 69, 311–317 (2014). https://doi.org/10.1134/S1061934814040133

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  • DOI: https://doi.org/10.1134/S1061934814040133

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