Abstract
Long-distance electron tunneling is a fundamental process which is involved in energy generation in cells. The tunneling occurs between the metal centers in the respiratory enzymes, typically over distances up to 20 or 30 such distances, the tunneling time—i.e., the time during which an electron passes through the body of the protein molecule from one metal center to another—is of the order of 10 fs. Here the process of electron tunneling in proteins is reviewed, and a possibility of experimental observation of real-time electron tunneling in a single protein molecule is discussed.
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References
V. P. Skulachev, Membrane Bioenergetics (Springer, Berlin, 1988).
D. G. Nicholls and S. J. Ferguson, Bioenergetics 3 (Elsevier Sci., San Diego, 2002).
D. DeVault and B. Chance, Biophys. J. 6, 825 (1966).
D. DeVault, Quantum Mechanical Tunneling in Biological Systems (Cambridge Univ., Cambridge, 1984).
H. B. Gray and J. R. Winkler, Ann. Rev. Biochem. 65, 537 (1996).
R. Langen, I. Chang, J. P. Germanas, J. H. Richards, J. R. Winkler, and H. B. Gray, Science 268, 1733 (1995).
C. C. Moser, J. M. Keske, K. Warncke, R. S. Farid, and L. P. Dutton, Nature 355, 796 (1992).
C. C. Page, C. C. Moser, X. Chen, and P. L. Dutton, Nature 402, 47 (1999).
S. S. Skourtis and D. Beratan, Adv. Chem. Phys. 106, 377 (1999).
R. A. Marcus and N. Sutin, Biochim. Biophys. Acta 811, 265 (1985).
M. Bixon and J. Jortner, Adv. Chem. Phys. 106, 35 (1999).
A. A. Stuchebrukhov, Theor. Chem. Acc. 110, 291 (2003).
A. A. Stuchebrukhov, J. Theor. Comp. Chem. 2, 91 (2003).
A. A. Stuchebrukhov, Adv. Chem. Phys. 118, 1 (2001).
M. D. Newton, Chem. Rev. 767, 91 (1991).
E. S. Medvedev and A. A. Stuchebrukhov, Pur. Appl. Chem. 70, 2201 (1998).
H. M. McConnel, J. Chem. Phys. 35, 508 (1961).
S. Larsson, J. Am. Chem. Soc. 103, 4034 (1981).
A. A. Stuchebrukhov and R. A. Marcus, J. Chem. Phys. 98, 8443 (1993).
J. M. Lopez-Castillo, A. Filali-Mouhim, I. L. Plante, and J. P. Jay-Gerin, J. Phys. Chem. 99, 6864 (1995).
A. Nitzan, J. Jortner, J. Wilkie, A. L. Burin, and M. A. Ratner, J. Phys. Chem. 104, 5661 (2000).
L. Y. Zhang, R. Murphy, and R. A. Friesner, J. Chem. Phys. 107, 450 (1997).
C. Liang and M. D. Newton, J. Phys. Chem. 96, 2855 (1992).
K. D. Jordan and M. N. Paddon-Row, J. Phys. Chem. 96, 1188 (1992).
K. Kim, K. D. Jordan, and M. N. Paddon-Row, J. Phys. Chem. 98, 11053 (1994).
R. Cave and M. D. Newton, Chem. Phys. Lett. 249, 15 (1996).
R. Cave and M. D. Newton, J. Chem. Phys. 106, 9213 (1997).
S. Larsson, J. Chem. Soc. Faraday Trans. 2, 1375 (1983).
P. Siddarth and R. A. Marcus, J. Phys. Chem. 94, 2985 (1993); J. Phys. Chem. 97, 2400 (1993).
J. W. Evenson and M. Karplus, Science 262, 1247 (1993).
M. Gruschus and A. Kuki, J. Phys. Chem. 97, 5581 (1993).
J. J. Regan, S. M. Risser, D. N. Beratan, and J. N. Onuchic, J. Phys. Chem. 97, 13083 (1993).
A. A. Stuchebrukhov, Chem. Phys. Lett. 225, 55 (1994).
A. A. Stuchebrukhov, Chem. Phys. Lett. 265, 643 (1997).
M. Ratner, J. Phys. Chem. 94, 4877 (1990).
D. J. Katz and A. A. Stuchebrukhov, J. Chem. Phys. 109, 4960 (1998).
I. Kurnikov and D. N. Beratan, J. Chem. Phys. 105, 9561 (1996).
J. N. Gehlen, I. Daizadeh, A. A. Stuchebrukhov, and R. A. Marcus, Inorg. Chim. Acta 243, 271 (1996).
J. N. Onuchic, D. N. Beratan, J. R. Winkler, and H. B. Gray, Science 258, 1740 (1992).
I. Daizadeh, D. M. Medvedev, and A. A. Stuchebrukhov, Molec. Biol. Evol. 19, 406 (2002).
D. M. Medvedev, I. Daizadeh, and A. A. Stuchebrukhov, J. Am. Chem. Soc. 122, 6571 (2000).
J. Kim and A. Stuchebrukhov, J. Phys. Chem. B 104, 8606 (2000).
J. F. Cushing and S. Goldstein, Bohmian Mechanics and Quantum Theory: An Apprisal (Kluwer Academic, Dordtecht, Holland, 1996).
A. A. Stuchebrukhov, J. Chem. Phys. 104, 8424 (1996).
A. A. Stuchebrukhov, J. Chem. Phys. 107, 6495 (1997).
A. A. Stuchebrukhov, J. Chem. Phys. 108, 8499 (1998).
J. Bardeen, Phys. Rev. Lett. 6, 57 (1961).
A. A. Stuchebrukhov, J. Chem. Phys. 108, 8510 (1998).
A. Szabo and N. S. Ostlund, Modern Quantum Chemistry (Macmillan, New York, 1982).
A. F. Voter and W. A. Goddard, Chem. Phys. 57, 253 (1981).
M. D. Newton, J. Phys. Chem. 92, 3049 (1988).
E. P. Bierwagen, T. R. Coley, and W. A. Goddard, Parallel Computing in Coputational Chemistry, ACS Symp. Ser., vol. 592, p. 84.
M. D. Newton, K. Ohta, and E. Zhong, J. Phys. Chem. 95, 2317 (1991).
A. A. Stuchebrukhov, J. Chem. Phys. 118, 7898 (2003).
X. H. Zheng and A. A. Stuchebrukhov, J. Phys. Chem. B 107, 9579 (2003).
Y. Georgievskii and A. A. Stuchebrukhov, J. Chem. Phys. 113, 10438 (2000).
I. Daizadeh, E. S. Medvedev, and A. A. Stuchebrukhov, Proc. Natl. Acad. Sci. USA 94, 3703 (1997).
I. Daizadeh, J. X. Guo, and A. Stuchebrukhov, J. Chem. Phys. 110, 8865 (1999).
J. Wang and A. A. Stuchebrukhov, Int. J. Quant. Chem. 80, 591 (2000).
N. E. Miller, M. C. Wander, and R. J. Cave, J. Phys. Chem. A 103, 1084 (1999).
I. A. Balabin and J. N. Onuchic, Science 114, 114 (2000).
E. S. Medvedev and A. A. Stuchebrukhov, J. Chem. Phys. 107, 3821 (1997).
R. Landauer and T. Martin, Rev. Mod. Phys. 66, 217 (1994).
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Stuchebrukhov, A.A. Long-distance electron tunneling in proteins: A new challenge for time-resolved spectroscopy. Laser Phys. 20, 125–138 (2010). https://doi.org/10.1134/S1054660X09170186
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DOI: https://doi.org/10.1134/S1054660X09170186