Skip to main content
SpringerLink
Log in

Amphiphilic star-shaped brushes based on block copolymers-molecular micelles for the delivery of drugs: Hydrodynamic studies

  • Solutions
  • Published:
Polymer Science Series A Aims and scope Submit manuscript

Abstract

Brush-shaped molecular stars of poly(ɛ-caprolactone)-block-poly(oligo(ethylene glycol) methacrylate) are synthesized, their hydrodynamic properties are studied, and their molecular characteristics are measured. For dilute solutions of the copolymers in acetone, viscous flow, velocity sedimentation, and translational diffusion of the macromolecules are investigated. The molecular masses of the copolymers are determined via the Svedberg relation. Correlations between hydrodynamic characteristics and molecular masses in the range 46 < M × 10−3 g mol−1 < 266 are obtained. The existence of scaling relationships makes it possible to infer that the resulting copolymers belong to a hydro-dynamically similar series of macromolecules: hydrodynamic homologs. It is shown that copolymer macromolecules have a denser organization in space than that of both linear macromolecules and conventional molecular stars. A model of macromolecules of poly(ɛ-caprolactone)-block-poly(oligo(ethylene glycol) methacrylate) copolymers that is based on their hydrodynamic characteristics is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. F. Panarin, N. A. Lavrov, M. V. Solovskii, and L. I. Shal’nova, Polymers-Carriers of Biologically Active Substances (TsOP “Professiya”, St. Petersburg, 2014) [in Russian].

    Google Scholar 

  2. L. Gros, H. Ringsdorf, and H. Schupp, Angew. Chem., Int. Ed. Engl. 20, 347 (1981).

    Article  Google Scholar 

  3. L. Y. Qiu and Y. H. Ba, Pharm. Res. 23, 1 (2006).

    Article  CAS  Google Scholar 

  4. R. Duncan, Nat. Rev. Drug Discovery 2, 347 (2003).

    Article  CAS  Google Scholar 

  5. O. G. Schramm, M. A. R. Meier, R. Hoogenboom, H. P. van Erp, J. -F. Gohy, U. S. Schubert, Soft Matter 5, 1662 (2009).

    Article  CAS  Google Scholar 

  6. O. G. Schramm, G. M. Pavlov, H. P. van Erp, M. A. R. Meier, R. Hoogenboom, U. S. Schubert, Macromolecules 42(6), 1808 (2009).

    Article  CAS  Google Scholar 

  7. K. Knop, G. M. Pavlov, T. Rudolph, K. Martin, D. Pretzel, B. O. Jahn, D. H. Scharf, A. A. Brakhage, V. Makarov, U. Mollmann, F. H. Schacher, U. S. Schubert, Soft Matter 9, 715 (2013).

    Article  CAS  Google Scholar 

  8. G. M. Pavlov, K. Knop, O. V. Okatova, and U. S. Schubert, Macromolecules 46, 8671 (2013).

    Article  CAS  Google Scholar 

  9. C. Tanford, Physical Chemistry of Macromolecules (Wiley, New York, 1961).

    Google Scholar 

  10. V. N. Tsvetkov, V. E. Eskin, and S. Y. Frenkel, Structure of Macromolecules in Solution (Nat. Lend. Library Sci. & Technol., Boston, 1971).

    Google Scholar 

  11. C. R. Cantor and P. R. Shimmel, Biophysical Chemistry (H. Freeman & Company, San Francisco, 1980).

    Google Scholar 

  12. G. M. Pavlov, “Hydrodynamic of Macromolecules: Conformation Zoning of General Macromolecules,” in Encyclopedia of Biophysics, Ed. by G. C. K. Roberts (Springer, Berlin, 2013), pp. 1014.

    Chapter  Google Scholar 

  13. P. Schuck, Biophys. J. 78, 1606 (2000).

    Article  CAS  Google Scholar 

  14. Sedfit, http://www.analyticalultracentrifugation.com.

  15. V. N. Tsvetkov, Rigid Chain Polymers (Plenum Press, New York, 1989).

    Google Scholar 

  16. V. P. Lavrenko and P. N. Lavrenko, Prog. Colloid Polym. Sci. 131, 23 (2006).

    Article  CAS  Google Scholar 

  17. V. P. Lavrenko, A. S. Gubarev, P. N. Lavrenko, O. V. Okatova, G. M. Pavlov, E. F. Panarin, Ind. Lab. (Diagn. Mater.) 79, 33 (2013).

    Google Scholar 

  18. G. M. Pavlov, A. S. Gubarev, I. I. Zaitseva, and M. A. Sibileva, Russ. J. Appl. Chem. 79(9), 1407 (2006).

    Article  CAS  Google Scholar 

  19. G. M. Pavlov and S. Ya. Frenkel, Prog. Colloid Polym. Sci 99, 101 (1995).

    Article  CAS  Google Scholar 

  20. G. M. Pavlov, I. Y. Perevyazko, O. V. Okatova, and U. S. Schubert, Methods 54(1), 124 (2011).

    Article  CAS  Google Scholar 

  21. G. M. Pavlov, Eur. Phys. J. E: Soft Matter Biol. Phys. 22(2), 171 (2007).

    Article  CAS  Google Scholar 

  22. M. Murat and K. J. Kremer, Chem. Phys. 108(10), 4340 (1998).

    CAS  Google Scholar 

  23. S. Sheiko and M. Möller, “Hyperbranched Macromolecules: Soft Particles with Adjustable Shape and Persistent Motion Capability,” in Dendrimers III, Ed. by F. Vögtle (Springer, Berlin, 2001), Vol. 212, p. 137.

    Chapter  Google Scholar 

  24. G. Zhang, K. C. Daoulas, and K. Kremer, Macromol. Chem. Phys. 214, 214 (2013).

    Article  CAS  Google Scholar 

  25. F. Eurich and P. Maass, J. Chem. Phys. 114(17), 7655 (2001).

    Article  CAS  Google Scholar 

  26. T. Vettorel, G. Besold, and K. Kremer, Soft Matter 6(10), 2282 (2010).

    Article  CAS  Google Scholar 

  27. F. Eurich, A. Karatchentsev, J. Baschnagel, W. Dieterich, P. Maass, J. Chem. Phys. 127(13), 134905 (2007).

    Article  CAS  Google Scholar 

  28. H. Ohshima, Langmuir 24(13), 6453 (2008).

    Article  CAS  Google Scholar 

  29. H. Ohshima, Colloids Surf. A 347(1) (2009).

    Google Scholar 

  30. C. I. J. Mendoza, Chem. Phys. 135(5), 054904 (2011).

    Google Scholar 

  31. P. Debye and A. M. J. Bueche, Chem. Phys. 16, 573 (1948).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bol’shoi pr. 31 (V.O.), St. Petersburg, 199004, Russia

    G. M. Pavlov & O. V. Okatova

  2. St. Petersburg State University, Ul’yanovskaya ul. 1, Petrodvorets, St. Petersburg, 198504, Russia

    G. M. Pavlov & A. S. Gubarev

  3. Institute of Organic and Macromolecular Chemistry, Friedrich-Schiller University, Humboldtstrasse 10, 07743, Jena, Germany

    G. M. Pavlov, K. Knop & U. S. Schubert

Authors
  1. G. M. Pavlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. V. Okatova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. S. Gubarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Knop
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. U. S. Schubert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. M. Pavlov.

Additional information

Original Russian Text © G.M. Pavlov, O.V. Okatova, A.S. Gubarev, K. Knop, U.S. Schubert, 2015, published in Vysokomolekulyarnye Soedineniya. Ser. A, 2015, Vol. 57, No. 2, pp. 112–119.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pavlov, G.M., Okatova, O.V., Gubarev, A.S. et al. Amphiphilic star-shaped brushes based on block copolymers-molecular micelles for the delivery of drugs: Hydrodynamic studies. Polym. Sci. Ser. A 57, 115–122 (2015). https://doi.org/10.1134/S0965545X15020133

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0965545X15020133

Keywords

Search

Navigation