Abstract
The interaction of Cu2+ ions with ampicillin, amoxicillin, and cephalexin (L) anions in an aqueous solution at 20°C with 0.1 M KNO3 as a background electrolyte was studied by pH-potentiometry. Formation of CuL+ and Cu(OH)L complexes was revealed, and their stability constants were determined.
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References
M. N. Hughes, Inorganic Chemistry of Biological Processes (Wiley, New York, 1981; Mir, Moscow, 1983).
A. P. Avtsin, A. A. Zhavoronkov, M. A. Rish, and L. S. Strochkova, Human Microelementoses (Meditsina, Moscow, 1991) [in Russian].
L. S. Strachunskii and S. N. Kozlov, Modern Antimicrobial Chemotherapy (Borges, Moscow, 2002) [in Russian].
V. G. Alekseev, E. V. Demskaya, and M. S. Dodonova, Zh. Obshch. Khim. 75(6), 1049 (2005) [Russ. J. Gen. Chem. 75 (6), 993 (2005)].
V. G. Alekseev, E. V. Demskaya, E. A. Milashs, and V. V. Igolkin, Zh. Obshch. Khim. 75(7), 1151 (2005).
V. G. Alekseev, V. S. Dalandutskaya, S. V. Markelova, and A. A. Avilkina, Zh. Obshch. Khim. 75(8), 1349 (2005) [Russ. J. Gen. Chem. 75 (8), 1280 (2005)].
V. G. Alekseev, S. V. Larin, O. Yu. Shigina, and E. E. Shcherbakova, Zh. Obshch. Khim. 76(2), 334 (2006) [Russ. J. Gen. Chem. 76 (2), 317 (2006)].
V. G. Alekseev, E. E. Shcherbakova, Yu. Ya. Yakubovich, et al., Zh. Obshch. Khim. 76(2), 338 (2006) [Russ. J. Gen. Chem. 76 (2), 321 (2006)].
V. G. Alekseev and L. V. Demskaya, Koord. Khim. 33(3), 211 (2007) [Russ. J. Coord. Chem. 33 (3), 203 (2007)].
V. G. Alekseev and V. G. Zamyslov, Koord. Khim. 33(4), 264 (2007) [Russ. J. Coord. Chem. 33 (4), 254 (2007)].
V. G. Alekseev, Zh. Neorg. Khim. 52(5), 763 (2007) [Russ. J. Inorg. Chem. 52 (5), 698 (2007)].
V. G. Alekseev, O. I. Lyamtseva, and I. S. Samuilova, Zh. Neorg. Khim. 52(3), 433 (2007) [Russ. J. Inorg. Chem. 52 (3), 383 (2007)].
V. G. Alekseev, A. A. Nikiforova, and S. V. Markelova, Zh. Obshch. Khim. 76(9), 1531 (2006) [Russ. J. Gen. Chem. 76 (9), 1468 (2006)].
El. Abd, M. G. Wahed, and M. Ayad, Anal. Lett. 17(B3), 205 (1984).
P. B. Issopoulos, J. Pharm. Biomed. Anal. 6(3), 321 (1988).
G. N. Mukherjee and T. K. Ghosh, Indian J. Chem. A 30, 1033 (1991).
A. Sher, M. Veber, M. Marolt-Gomiscek, and S. Gomiscek, Int. J. Pharm. 90(3), 181 (1993).
A. Sher, M. Veber, M. Marolt-Gomiscek, and S. Gomiscek, Int. J. Pharm. 99(2–3), 119 (1993).
M. M. Shoukry, Anal. Chim. 83, 147 (1993).
G. N. Mukherjee and T. K. Ghosh, J. Inorg. Biochem. 59(4), 827 (1995).
G. N. Mukherjee and T. K. Ghosh, Proc. Indian Acad. Sci. (Chem. Sci.) 108(4), 371 (1996).
M. J. Zaworotko, H. H. Hammud, I. Abbas, et al., J. Coord. Chem. 59(1), 65 (2006).
A. Bravo and J. R. Anacona, J. Coord. Chem. 44(1), 173 (1998).
J. R. Anacona, J. Coord. Chem. 54(3), 355 (2001).
Inorganic Biochemistry, Ed. by G. L. Eichhorn (Elsevier, Amsterdam, 1975; Mir, Moscow, 1978), Vol. 1.
A. Fernandez-Gonzalez, R. Badia, and M. E. Diaz-Garcia, Anal. Biochem. 341(1), 113 (2005).
K. V. Zaitseva and V. G. Alekseev, Vestn. Tversk. Gos. Univ., No. 8 (2006).
V. A. Nazarenko, V. P. Antonovich, and E. M. Nevskaya, Hydrolysis of Metal Ions in Diluted Solutions (Atomizdat, Moscow, 1979) [in Russian].
W. L. Marshall and E. U. Frank, J. Phys. Chem. Ref. Data 10(2), 295 (1981).
W. J. Hamer and Y. C. Wu, J. Phys. Chem. Ref. Data 1(4), 1047 (1972).
K. B. Yatsimirskii, E. E. Kriss, and V. L. Gvyazdovskaya, Stability Constants of Metal Complexes with Biometals (Naukova Dumka, Kiev, 1979) [in Russian].
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Original Russian Text © S.V. Lapshin, V.G. Alekseev, 2009, published in Zhurnal Neorganicheskoi Khimii, 2009, Vol. 54, No. 7, pp. 1127–1130.
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Lapshin, S.V., Alekseev, V.G. Copper(II) complexation with ampicillin, amoxicillin, and cephalexin. Russ. J. Inorg. Chem. 54, 1066–1069 (2009). https://doi.org/10.1134/S0036023609070122
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DOI: https://doi.org/10.1134/S0036023609070122