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One-pot three-component Mannich reaction catalyzed by iodine under solvent-free conditions

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Abstract

One-pot three-component Mannich reactions of ketones with aromatic aldehydes and aromatic amines are effectively catalyzed by molecular iodine at room temperature under solvent-free conditions to afford the corresponding β-amino carbonyl compounds with moderate to excellent yields. The method has the following advantages: no use of solvent, mild condition, high reaction speed and small quantity of catalyst.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, China

    Li Gang & Yang Jiangli

  2. Department of Life Science and Technology, Xinxiang Medical University, Xinxiang, China

    Long Ruiling

Authors
  1. Li Gang
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  2. Long Ruiling
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  3. Yang Jiangli
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Correspondence to Li Gang.

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Gang, L., Ruiling, L. & Jiangli, Y. One-pot three-component Mannich reaction catalyzed by iodine under solvent-free conditions. Kinet Catal 52, 397–400 (2011). https://doi.org/10.1134/S0023158411030062

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  • DOI: https://doi.org/10.1134/S0023158411030062

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