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Production of Lidocaine Nanoforms via the Rapid Extension of a Supercritical Solution into Water Medium

  • HEAT AND MASS TRANSFER AND PHYSICAL GASDYNAMICS
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High Temperature Aims and scope

Abstract

The pharmaceutical substances of a group of local anesthetics, in particular, the drug lidocaine, are the object of the study. The influence of the thermodynamic parameters of the state on the process of lidocaine dispersion via the rapid expansion of a supercritical solution in an aqueous medium (RESAS) is studied in this work. The experiments were carried out at saturation temperatures of 40 and 60°C, a temperature of the expansion device of 40°C, and a system pressure of 15–35 MPa. The structure of the obtained particles was analyzed with a D8 ADVANCE diffractometer (before and after grinding). The melting points of the initial and processed lidocaine substance were determined.

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Funding

The study was supported by the Russian Foundation for Basic Research, project no. 18-79-00064.

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Authors and Affiliations

  1. Kazan National Research Technological University, 420015, Kazan, Russia

    I. V. Kuznetsova, I. I. Gilmutdinov, I. M. Gilmutdinov & A. N. Sabirzyanov

Authors
  1. I. V. Kuznetsova
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  2. I. I. Gilmutdinov
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  3. I. M. Gilmutdinov
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  4. A. N. Sabirzyanov
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Correspondence to I. V. Kuznetsova.

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Kuznetsova, I.V., Gilmutdinov, I.I., Gilmutdinov, I.M. et al. Production of Lidocaine Nanoforms via the Rapid Extension of a Supercritical Solution into Water Medium. High Temp 57, 726–730 (2019). https://doi.org/10.1134/S0018151X19040138

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  • DOI: https://doi.org/10.1134/S0018151X19040138

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