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Cell response to extremely weak static magnetic fields

  • Cell Biophysics
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Abstract

The effect of an extremely weak static magnetic field (EWSMF) was studied in diploid fibroblast strains that originated from a healthy donor and an ataxia–telangiectasia patient. Indirect immunofluorescence was used to detect p53, p53BP1, and p21. The pattern that occurred in donor cells exposed to EWSMF similar to that observed in DNA damage, viz., the p53 and p21 levels increased and p3BP1 foci formed. No visible change was observed in primary fibroblasts from the ataxia–telangiectasia patient. The results implicate ATM signaling in the fibroblast response to EWSMF.

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Abbreviations

MF:

magnetic field

EWSMF:

extremely weak static MF

AT:

ataxia–telangiectasia

DDR:

DNA damage response

DSB:

double-strand break

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Authors and Affiliations

  1. Institute of Cytology, Russian Academy of Sciences, Tikhoretskii pr. 4, St. Petersburg, 194064, Russia

    I. M. Spivak & M. L. Kuranova

  2. St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia

    I. M. Spivak, G. R. Mavropulo-Stolyarenko & V. E. Stefanov

  3. St. Petersburg Polytechnic University, ul. Politekhnicheskaya 29, St. Petersburg, 195251, Russia

    I. M. Spivak

  4. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    S. V. Surma & B. F. Shchegolev

  5. Almazov Federal Medical Research Center, Ministry of Health of the Russian Federation, ul. Akkuratova 2, St. Petersburg, 197341, Russia

    B. F. Shchegolev

Authors
  1. I. M. Spivak
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  2. M. L. Kuranova
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  3. G. R. Mavropulo-Stolyarenko
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  4. S. V. Surma
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  5. B. F. Shchegolev
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  6. V. E. Stefanov
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Corresponding author

Correspondence to V. E. Stefanov.

Additional information

Original Russian Text © I.M. Spivak, M.L. Kuranova, G.R. Mavropulo-Stolyarenko, S.V. Surma, B.F. Shchegolev, V.E. Stefanov, 2016, published in Biofizika, 2016, Vol. 61, No. 3, pp. 516–522.

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Spivak, I.M., Kuranova, M.L., Mavropulo-Stolyarenko, G.R. et al. Cell response to extremely weak static magnetic fields. BIOPHYSICS 61, 435–439 (2016). https://doi.org/10.1134/S0006350916030180

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  • DOI: https://doi.org/10.1134/S0006350916030180

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