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Fullerenes C60, antiamyloid action, the brain, and cognitive processes

  • Cell Biophysics
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Abstract

A short review of investigations along a new line: the antiamyloid action of fullerenes C60 and correction of disturbed cognitive processes is presented. The prospects for the development of drugs based on fullerenes acting on the key molecular mechanisms at the early stage of Alzheimer’s disease are discussed.

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Abbreviations

C60 :

fullerene

ROS:

reactive oxygen species

Aβ:

amyloid β-peptide

FWS:

colloidal water suspension of fullerene

AD:

Alzheimer’s disease

NMDA:

N-methyl-D-aspartate

AMPA:

α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid

LTP:

long-term potentiation

PS:

population spike

PVP:

polyvinyl pyrrolidone

AIDS:

acquired immune deficiency syndrome

HF:

high frequency

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    I. Ya. Podolski, Z. A. Podlubnaya & O. V. Godukhin

  2. Pushchino State University, Pushchino, Moscow Region, 142290, Russia

    O. V. Godukhin

Authors
  1. I. Ya. Podolski
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  2. Z. A. Podlubnaya
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  3. O. V. Godukhin
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Correspondence to I. Ya. Podolski.

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Dedicated to the memory of a remarkable scientist and humanist Levon Mikhailovich Chailakhyan

Original Russian Text © I.Ya. Podolski, Z.A. Podlubnaya, O.V. Godukhin, 2010, published in Biofizika, 2010, Vol. 55, No. 1, pp. 88–94.

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Podolski, I.Y., Podlubnaya, Z.A. & Godukhin, O.V. Fullerenes C60, antiamyloid action, the brain, and cognitive processes. BIOPHYSICS 55, 71–76 (2010). https://doi.org/10.1134/S0006350910010136

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  • DOI: https://doi.org/10.1134/S0006350910010136

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