Skip to main content
SpringerLink
Log in

X-ray studies of biological macromolecules at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences

  • Structure of Macromolecular Compounds
  • Published:
Crystallography Reports Aims and scope Submit manuscript

Abstract

The results of X-ray diffraction studies of a number of proteins and the carnation mottle virus performed over a period from 1970 to 2000 at the laboratory created by Academician B.K. Vainshtein at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences are surveyed. The fundamental principles of the spatial organization of protein structures are considered. The characteristic features of the three-dimensional structures of a number of various proteins performing various functions are discussed including leghemoglobin, catalases, pyrophosphatases, pyridoxal-dependent enzymes, nucleotide depolymerases, proteases, and plant toxins. The results obtained for carnation mottle virus are summarized. The contribution of X-ray diffraction studies to the understanding of mechanisms of functioning of the above macromolecules and the first stages of the crystallographic studies of nucleic-acid fragments are discussed. The present state and the prospects of studies of three-dimensional structures of macromolecules are also considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. D. Bernal and D. Crowfoot, Nature 133, 794 (1934).

    Google Scholar 

  2. D. W. Green, V. M. Ingram, and M. F. Perutz, Proc. R. Soc. London, Ser. A 255, 287 (1954).

    ADS  Google Scholar 

  3. J. C. Kendrew, G. Bodo, H. M. Dintzis, et al., Nature 181, 662 (1958).

    Google Scholar 

  4. J. C. Kendrew, R. E. Dickerson, and B. E. Strandberg, Nature 185, 422 (1960).

    Google Scholar 

  5. M. F. Perutz, M. G. Rossman, A. G. Guillis, et al., Nature 185, 416 (1960).

    Google Scholar 

  6. A. A. Vagin, Candidate’s Dissertation in Physics and Mathematics (Inst. Kristallografii Akad. Nauk SSSR, Moscow, 1989).

    Google Scholar 

  7. B. K. Vainshtein, in Problems of the Theory of Symmetry in Application to Macromolecules and Biocrystals (Nauka, Moscow, 1987), p. 9.

    Google Scholar 

  8. B. K. Vainshtein, Usp. Fiz. Nauk 152(1), 75 (1987) [Sov. Phys. Usp. 30, 393 (1987)].

    Google Scholar 

  9. B. K. Vainshtein and A. B. Goncharov, Dokl. Akad. Nauk SSSR 287, 1131 (1986) [Sov. Phys. Dokl. 31, 278 (1986)].

    MathSciNet  Google Scholar 

  10. A. B. Goncharov, B. K. Vainshtein, and A. I. Ryskin, Kristallografiya 32(5), 858 (1987) [Sov. Phys. Crystallogr. 32, 504 (1987)].

    Google Scholar 

  11. B. K. Vainshtein, Comput. Math. Appl. B 12, 237 (1986).

    MathSciNet  Google Scholar 

  12. I. P. Kuranova, A. I. Grebenko, N. V. Konareva, et al., Biokhimiya 41, 1603 (1975).

    Google Scholar 

  13. B. K. Vainshtein, E. G. Harutyunyan, I. P. Kuranova, et al., Nature 254, 163 (1975).

    Article  Google Scholar 

  14. B. K. Vainshtein, É. G. Harutyunyan, I. P. Kuranova, et al., Dokl. Akad. Nauk SSSR 216, 690 (1975).

    Google Scholar 

  15. B. K. Vainshtein, É. G. Harutyunyan, I. P. Kuranova, et al., Kristallografiya 23(3), 517 (1978) [Sov. Phys. Crystallogr. 23, 287 (1978)].

    Google Scholar 

  16. B. K. Vainshtein, I. P. Kuranova, É. G. Harutyunyan, et al., Bioorg. Khim. 6, 684 (1980).

    Google Scholar 

  17. É. G. Harutyunyan, I. P. Kuranova, B. K. Vainshtein, et al., Kristallografiya 25(1), 80 (1980) [Sov. Phys. Crystallogr. 25, 43 (1980)].

    Google Scholar 

  18. É. G. Harutyunyan, I. P. Kuranova, A. B. Tovbis, et al., Kristallografiya 25(3), 526 (1980) [Sov. Phys. Crystallogr. 25, 302 (1980)].

    Google Scholar 

  19. I. P. Kuranova, A. V. Teplyakov, G. V. Obmolova, et al., Bioorg. Khim. 8, 1625 (1982).

    Google Scholar 

  20. E. H. Harutyunyan, T. N. Safonova, I. P. Kuranova, et al., J. Mol. Biol. 264, 152 (1996).

    Article  Google Scholar 

  21. E. H. Harutyunyan, T. N. Safonova, I. P. Kuranova, et al., J. Mol. Biol. 251, 104 (1995).

    Article  Google Scholar 

  22. B. K. Vainshtein, V. R. Melik-Adamyan, V. V. Barynin, et al., Dokl. Akad. Nauk SSSR 246, 220 (1979).

    Google Scholar 

  23. B. K. Vainshtein, V. R. Melik-Adamyan, V. V. Barynin, et al., Dokl. Akad. Nauk SSSR 250, 242 (1980).

    Google Scholar 

  24. B. K. Vainshtein, V. R. Melik-Adamyan, V. V. Barynin, et al., Acta Crystallogr., Sect. A: Cryst. Phys., Diffr., Theor. Gen. Crystallogr. 37, C29 (1981).

    Google Scholar 

  25. B. K. Vainshtein, V. R. Melik-Adamyan, V. V. Barynin, et al., Nature 293, 411 (1981).

    Article  Google Scholar 

  26. B. K. Vainshtein, V. R. Melik-Adamyan, V. V. Barynin, et al., J. Mol. Biol. 188, 63 (1986).

    Article  Google Scholar 

  27. V. R. Melik-Adamyan, V. V. Barynin, A. A. Vagin, et al., J. Mol. Biol. 188, 49 (1986).

    Google Scholar 

  28. V. R. Melik-Adamyan, V. V. Barynin, A. A. Vagin, et al., Kristallografiya 32(3), 638 (1987) [Sov. Phys. Crystallogr. 32, 372 (1987)].

    Google Scholar 

  29. V. R. Melik-Adamyan, V. V. Barynin, A. A. Vagin, et al., Kristallografiya 32(3), 653 (1987) [Sov. Phys. Crystallogr. 32, 382 (1987)].

    Google Scholar 

  30. V. R. Melik-Adamyan, A. I. Grebenko, V. V. Barynin, et al., Dokl. Akad. Nauk SSSR 306, 620 (1989) [Sov. Phys. Dokl. 34, 404 (1989)].

    Google Scholar 

  31. G. N. Murshudov, V. R. Melik-Adamyan, A. I. Grebenko, et al., FEBS Lett. 312, 127 (1992).

    Article  Google Scholar 

  32. G. N. Murshudov, A. I. Grebenko, V. V. Barynin, et al., J. Biol. Chem. 271, 8863 (1992).

    Google Scholar 

  33. V. V. Barynin and V. R. Melik-Adamyan, Kristallografiya 27(5), 981 (1982) [Sov. Phys. Crystallogr. 27, 588 (1982)].

    Google Scholar 

  34. M. M. Barynin, A. A. Vagin, V. R. Melik-Adamyan, et al., Dokl. Akad. Nauk SSSR 288, 877 (1986) [Sov. Phys. Dokl. 31, 457 (1986)].

    Google Scholar 

  35. V. V. Barynin, A. A. Vagin, V. R. Melik-Adamyan, et al., Dokl. Akad. Nauk SSSR 306, 620 (1989) [Sov. Phys. Dokl. 34, 404 (1989)].

    Google Scholar 

  36. S. V. Antonyuk, V. R. Melik-Adamyan, A. N. Popov, et al., Kristallografiya 45(1), 111 (2000) [Crystallogr. Rep. 45, 105 (2000)].

    Google Scholar 

  37. A. E. Braunshtein, É. G. Harutyunyan, and V. N. Malashkevich, Mol. Biol. 19, 196 (1985).

    Google Scholar 

  38. V. V. Borisov, S. N. Borisova, N. I. Sosfenov, et al., Dokl. Akad. Nauk SSSR 250, 288 (1980).

    MathSciNet  Google Scholar 

  39. V. V. Borisov, S. N. Borisova, G. I. Kachalova, et al., in Transaminases, Ed. by P. Christen and D. E. Metzler (Wiley, New York, 1985), p. 155.

    Google Scholar 

  40. V. N. Malashkevich, B. V. Strokopitov, V. V. Borisov, et al., J. Mol. Biol. 247, 111 (1995).

    Article  Google Scholar 

  41. A. A. Antson, B. V. Strokopytov, G. N. Murshudov, et al., Kristallografiya 37(1), 82 (1992) [Sov. Phys. Crystallogr. 37, 40 (1992)].

    Google Scholar 

  42. A. A. Antson, B. V. Strokopytov, G. N. Murshudov, et al., FEBS Lett. 302, 256 (1992).

    Article  Google Scholar 

  43. A. A. Antson, B. V. Strokopytov, T. V. Demidkina, et al., Acta Crystallogr., Sect. A: Found. Crystallogr. 46, C132 (1990).

    Google Scholar 

  44. A. A. Antson, T. V. Demidkina, P. Gollnick, et al., Biochemistry 32, 4195 (1993).

    Article  Google Scholar 

  45. S. V. Pletnev, A. A. Antson, N. I. Sinitsyna, et al., Kristallografiya 42(5), 877 (1997) [Crystallogr. Rep. 42, 809 (1997)].

    Google Scholar 

  46. M. N. Isupov, A. A. Antson, E. J. Dodson, et al., J. Mol. Biol. 276, 603 (1998).

    Article  Google Scholar 

  47. M. Isupov, I. Dementieva, I. Zakomirdina, et al., in Biochemistry of Vitamin B 6 and PQQ, Ed. by G. Marino, G. Samnia, and F. Bossa (Birkchauser Verlag, Basel, 1987).

    Google Scholar 

  48. A. G. Pavlovskii, B. V. Strokopytov, and S. N. Borisova, Dokl. Akad. Nauk SSSR 292, 1253 (1987).

    Google Scholar 

  49. K. M. Polyakov, B. K. Vainshtein, G. N. Tishchenko, et al., Dokl. Akad. Nauk SSSR 273, 1383 (1983) [Sov. Phys. Dokl. 28, 988 (1983)].

    Google Scholar 

  50. A. G. Pavlovskii, B. V. Strokopytov, S. N. Borisova, et al., Kristallografiya 31(3), 476 (1986) [Sov. Phys. Crystallogr. 31, 279 (1986)].

    Google Scholar 

  51. K. M. Polyakov, B. M. Strokopytov, B. K. Vainshtein, et al., Kristallografiya 32(4), 918 (1987) [Sov. Phys. Crystallogr. 32, 539 (1987)].

    Google Scholar 

  52. A. G. Pavlovskii, R. G. Sanishvili, S. N. Borisova, et al., Kristallografiya 34(1), 137 (1989) [Sov. Phys. Crystallogr. 34, 79 (1989)].

    Google Scholar 

  53. J. Sevcik, R. G. Sanishvili, K. M. Polyakov, et al., Trends Biochem. Sci. 15, 158 (1990).

    Article  Google Scholar 

  54. V. Yu. Lunin, V. M. Levdikov, S. V. Shlyapnikov, et al., FEBS Lett. 412, 217 (1997).

    Article  Google Scholar 

  55. S. V. Shlyapnikov, E. V. Blagova, V. M. Levdikov, et al., Mol. Biol. 33, 454 (1999).

    Google Scholar 

  56. S. V. Shlyapnikov, V. V. Lunin, M. Perbandt, et al., Acta Crystallogr., Sect. D: Biol. Crystallogr. 56, 567 (2000).

    Article  Google Scholar 

  57. I. P. Kuranova, E. A. Smirnova, V. V. Makhaldiani, et al., Dokl. Akad. Nauk SSSR 258, 1245 (1981).

    Google Scholar 

  58. I. P. Kuranova, S. S. Terzyan, A. A. Voronova, et al., Bioorg. Khim. 9, 1611 (1983).

    Google Scholar 

  59. É. G. Harutyunyan, S. S. Terzyan, A. A. Voronova, et al., Dokl. Akad. Nauk SSSR 258, 1480 (1981).

    Google Scholar 

  60. S. S. Terzyan, A. A. Voronova, E. A. Smirnova, et al., Bioorg. Khim. 10, 1469 (1984).

    Google Scholar 

  61. I. P. Kuranova, Biokhimiya 53, 1821 (1988).

    Google Scholar 

  62. E. G. Harutyunyan, I. P. Kuranova, B. K. Vainshtein, et al., Eur. J. Biochem. 239, 220 (1996).

    Article  Google Scholar 

  63. I. P. Kuranova, G. V. Obmolova, and N. V. Konareva, Dokl. Akad. Nauk SSSR 295, 1013 (1987).

    Google Scholar 

  64. A. V. Teplyakov, G. V. Obmolova, I. P. Kuranova, et al., Protein Sci. 3, 1098 (1994).

    Google Scholar 

  65. E. G. Harutyunyan, V. Yu. Oganessyan, N. N. Oganessyan, et al., Biochemistry 36, 7754 (1997).

    Article  Google Scholar 

  66. S. M. Avaeva, E. V. Rodina, N. N. Vorob’eva, et al., Biokhimiya 63, 797 (1998).

    Google Scholar 

  67. S. M. Avaeva, N. N. Vorob’eva, S. A. Kurilova, et al., Biokhimiya 65, 442 (2000).

    Google Scholar 

  68. T. Salminen, A. Teplyakov, Yu. Kancare, et al., Protein Sci. 5, 1014 (1996).

    Google Scholar 

  69. V. R. Samigina, S. V. Antonyuk, V. S. Lamzin, et al., Acta Crystallogr., Sect. D. Biol. Crystallogr. 56, 595 (2000).

    Google Scholar 

  70. A. Teplyakov, K. Polyakov, I. Kuranova, et al., Eur. J. Biochem. 208, 281 (1992).

    Article  Google Scholar 

  71. A. V. Teplyakov, I. P. Kuranova, B. K. Vainshtein, et al., J. Mol. Biol. 214, 261 (1990).

    Article  Google Scholar 

  72. S. N. Borisova, A. G. Pavlovskii, B. K. Vainshtein, et al., Dokl. Akad. Nauk SSSR 301, 474 (1988).

    Google Scholar 

  73. A. G. Pavlovskii, S. N. Borisova, B. V. Strokopitov, et al., Dokl. Akad. Nauk SSSR 305, 861 (1989) [Sov. Phys. Dokl. 34, 280 (1989)].

    Google Scholar 

  74. A. G. Tonevitskii, D. E. Temyakov, E. C. Sweeney, et al., Kristallografiya 41(6), 1018 (1996) [Crystallogr. Rep. 41, 966 (1996)].

    Google Scholar 

  75. E. V. Vernoslova, N. V. Konareva, A. M. Mikhailov, et al., Kristallografiya 44(4), 630 (1999) [Crystallogr. Rep. 44, 582 (1999)].

    Google Scholar 

  76. V. M. Levdikov, A. I. Grebenko, V. V. Barynin, et al., Kristallografiya 41(2), 293 (1996) [Crystallogr. Rep. 41, 275 (1996)].

    Google Scholar 

  77. V. M. Levdikov, V. V. Barynin, A. I. Grebenko, et al., Structure (London) 6, 363 (1998).

    Google Scholar 

  78. E. Yu. Morgunova, A. S. Kaftanova, A. V. Kulinin, et al., Dokl. Akad. Nauk SSSR 276, 119 (1984) [Sov. Phys. Dokl. 29, 357 (1984)].

    Google Scholar 

  79. A. T. Dembo, E. Yu. Morgunova, B. V. Mchedleshvili, et al., Kristallografiya 32(6), 1414 (1987) [Sov. Phys. Crystallogr. 32, 831 (1987)].

    Google Scholar 

  80. E. Yu. Morgunova, A. M. Mikhailov, Yu. V. Nekrasov, et al., Dokl. Akad. Nauk SSSR 299, 1129 (1988) [Sov. Phys. Dokl. 33, 239 (1988)].

    Google Scholar 

  81. E. Yu. Morgunova, A. M. Mikhailov, A. I. Nikitenko, et al., Dokl. Akad. Nauk SSSR 305, 489 (1989).

    Google Scholar 

  82. E. Yu. Morgunova, A. M. Mikhailov, and B. K. Vainshtein, Mol. Biol. 27, 371 (1993).

    Google Scholar 

  83. E. Yu. Morgunova, Z. Dauter, E. Fry, et al., FEBS Lett. 338, 267 (1994).

    Article  Google Scholar 

  84. L. V. Malinina, V. V. Makhaldiani, B. K. Vainshtein, et al., Dokl. Akad. Nauk SSSR 248, 229 (1985).

    Google Scholar 

  85. L. V. Malinina, V. V. Makhaldiani, B. K. Vainshtein, et al., Mol. Biol. 21, 529 (1987).

    Google Scholar 

  86. L. V. Malinina, V. A. Tereshko, A. A. Vagin, et al., Mol. Biol. 21, 1142 (1987).

    Google Scholar 

  87. V. A. Tereshko and L. V. Malinina, Mol. Biol. 23, 1163 (1989).

    Google Scholar 

  88. L. Malinina, V. Tereshko, Z. Ivanova, et al., J. Cryst. Growth 110, 252 (1991).

    Article  Google Scholar 

  89. V. Strokopitov and L. Malinina, J. Biomol. Struct. Dyn. 11, 1049 (1994).

    Google Scholar 

  90. D. E. Klimenko, B. K. Chernov, and L. V. Malinina, J. Biomol. Struct. Dyn. 13, 529 (1995).

    Google Scholar 

  91. A. M. Mikhailov, A. V. Nikitenko, and E. V. Chetverina, Bioorg. Khim. 17, 372 (1991).

    Google Scholar 

  92. V. S. Lamzin, Z. Dauter, E. G. Harutyunyan, et al., J. Mol. Biol. 236, 759 (1994).

    Article  Google Scholar 

  93. É. G. Harutyunyan, J. Deisenhofer, and A. V. Teplyakov, Dokl. Akad. Nauk SSSR 270, 732 (1983).

    Google Scholar 

  94. E. Yu. Morgunova, A. M. Mikhailov, A. N. Popov, et al., FEBS Lett. 367, 183 (1995).

    Article  Google Scholar 

  95. É. G. Harutyunyan, I. Yu. Oganessyan, N. N. Oganessyan, et al., Kristallografiya 41(1), 84 (1996) [Crystallogr. Rep. 41, 77 (1996)].

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shubnikov Institute of Crystallography, Russian Academy of Sciences, Leninskii pr. 59, Moscow, 117333, Russia

    I. P. Kuranova

Authors
  1. I. P. Kuranova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to the memory of B.K. Vainshtein

__________

Translated from Kristallografiya, Vol. 46, No. 4, 2001, pp. 667–686.

Original Russian Text Copyright © 2001 by Kuranova.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuranova, I.P. X-ray studies of biological macromolecules at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences. Crystallogr. Rep. 46, 601–619 (2001). https://doi.org/10.1134/1.1387126

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1134/1.1387126

Keywords

Search

Navigation