耳鼻と臨床
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
耳鼻咽喉科領域感染症におけるFlomoxef (6315-S) の基礎的,臨床的検討
馬場 駿吉, 稲垣 光昭, 海野 徳二, 上戸 敏彦, 柳内 統, 野中 聡, 市川 良之, 古内 一郎, 河村 正三, 芳川 洋, 桜井 淳, 板橋 隆嗣, 和田 昌士, 藤巻 豊, 渡辺 洋, 野村 恭也, 仙波 哲雄, 鳥山 寧二, 渡辺 博紀, 市村 恵一, 庄司 稔, 三宅 浩郷, 新川 敦, 坂本 裕, 大西 信治郎, 西村 忠郎, 鈴木 昭男, 丸尾 猛, 伊藤 晴夫, 松永 亨, 浅井 英世, 玉置 弘光, 金 聖真, 石田 稔, 田矢 直三, 松永 喬, 岩崎 壽美, 柏木 令子, 梁川 明久, 北奥 恵之, 折田 洋造, 秋定 健, 涌谷 忠雄, 藤野 有弘, 寺嶋 正治, 尾中 良久, 関谷 透, 沖中 芳彦, 平田 哲康, 日吉 正明, 齋藤 春雄, 木村 正, 茂木 五郎, 黒野 祐一, 佐藤 春生, 弓崎 明輝, 吉村 弘之, 進 武幹, 渡部 俊, 古川 満, 森満 保, 林 明俊, 笠野 藤彦, 牧野 浩二, 柊山 幹子, 永井 みどり, 松元 一郎, 東野 哲也, 大山 勝, 古田 茂, 矢野 博美, 深水 浩三, 伊東 一則, 大野 聖, 大野 郁夫, 出口 浩一
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キーワード: 耳鼻咽喉科感染症
ジャーナル フリー

1989 年 35 巻 2Supplement1 号 p. 394-409

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Fundamental and clinical evaluations of the safety and effectivity of FMOX in treating diseases caused by bacterial infections concerning the otorhinolaryngological field were done, and the following results were obtained. 1. FMOX was effective against S. aureus, S. pyogenes, Klebsiella sp., H. influenzae, B. catarrhalis, Anaerobic streptococci and Peptostreptococcus sp. isolated from patients with Various types of otorhinolaryngological infections, most notably, suppurative otitis media. The following data correspond to the MIC of FMOX for each of the above bacteria:≤6.25μg/ml, ≤0.78μg/ml, ≤0.39μg/ml, ≤0.78μg/ml, ≤0.78μg/ml, ≤1.56μg/ ml and≤0.78μg/ml, respectiVely. For S. aureus, FMOX had a far greater antibacterial effect than CTM or LMOX. 2. The maximum concentration in tissue (Cmax) of 1g FMOX administered intravenously, was 25.6μg/g in the middle ear and 11.1μg/ml in the tonsils. 3. The percent efficiency of FMOX was measured against a standardized evaluation. FMOX was 56.9% effective against otitis media, 93.4% effective against tonsillitis, 100% effective against pharyngitis and laryngitis, and 75.2% effective against all infections. Physicians evaluated FMOX to have an efficacy of 79.7% against all infections. 4. The rate of bacterial disappearance was high: in infections of Gram-positive bacteria alone, 89.8%, and 75.0% in infections of Gram-negative bacteria alone. FMOX was also rated high at dealing with complex bacterial infections, including those with S. aureus. 5. The percent utility of FMOX was 62.1% against otitis media, 96.7% against tonsillitis, 64.7% against other infections, and 76.5% against all infections. 6. Mild side effects were noted in 5 patients (2.8%: gastrointestinal symptoms and hypersensitivity of the skin). Laboratory examinations uncovered abnormal findings primarily suggesting mild hepatic and renal dysfunction in 7 patients (6.2%), but these Were all temporary. From these results, FMOX is considered to be highly useful for the treatment of otorhinolaryngological infections, most notably suppurative otitis media.

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