2020 年 69 巻 3 号 p. 214-220
Methotrexate (MTX) is an anticancer agent and immunosuppressant that is particularly useful in rheumatoid arthritis (RA). It is frequently used as a standard therapeutic agent for RA. MTX-associated lymphoproliferative disorder (MTX-LPD) is a lymphoma that appears with long-term administration of MTX, and presents with extranodal lesions in the gastrointestinal tract, skin, lungs and soft tissue compared with other lymphomas. Additionally, recent reports have described lesions in oral areas such as the gingiva, tongue and oral floor, but there are no reports of cases in Japan or overseas of MTX-LPD lesions appearing as cystic lesions of the mandible on radiographs. Herein we report a case of MTX-related Hodgkin’s lymphoma which was difficult to distinguish from a cystic lesion in the jaw bone.