1) The concentration in blood of a new synthetic penicillin PC-904 was measured in patients with impaired renal function. The results indicated that the blood level of the penicillin was lowered more quickly in cases of renal failure than in those with mild impairment of renal function.
2) PC-904 was administered alone to a total of 22 hospitalized patients (with 6 of them having renal failure) comprising 8 with respiratory infection, 8 with abdominal or biliary tract infection and 6 with urinary tract infection. The clinical effect of this antibiotic therapy was rated as excellent or good in 13 cases, as fair in 3 cases and as none or failure in 6 cases. It seems that the drug, when given at a daily dose of less than 1 g, may not be anticipated to prove of therapeutic benefit irrespective of the degree of integrity of renal function.
3) Side effects were encountered 12 times in 10 of the entire 22 cases treated. While a fever and skin eruptions, seen in 5 instances, appeared to be rather high in incidence, eosinophilia, seen in 4 instances, does not seem to be a significant problem.