Brain tumor modeling: glioma growth and interaction with chemotherapy

Hossein Yousefi Banaem; Alireza Ahmadian; Hooshangh Saberi; Alireza Daneshmehr; Davood Khodadad

doi:10.1117/12.913432

30 September 2011 Brain tumor modeling: glioma growth and interaction with chemotherapy

Hossein Yousefi Banaem, Alireza Ahmadian, Hooshangh Saberi, Alireza Daneshmehr, Davood Khodadad

Proceedings Volume 8285, International Conference on Graphic and Image Processing (ICGIP 2011); 82851M (2011) https://doi.org/10.1117/12.913432
Event: 2011 International Conference on Graphic and Image Processing, 2011, Cairo, Egypt

Abstract

In last decade increasingly mathematical models of tumor growths have been studied, particularly on solid tumors which growth mainly caused by cellular proliferation. In this paper we propose a modified model to simulate the growth of gliomas in different stages. Glioma growth is modeled by a reaction-advection-diffusion. We begin with a model of untreated gliomas and continue with models of polyclonal glioma following chemotherapy. From relatively simple assumptions involving homogeneous brain tissue bounded by a few gross anatomical landmarks (ventricles and skull) the models have been expanded to include heterogeneous brain tissue with different motilities of glioma cells in grey and white matter. Tumor growth is characterized by a dangerous change in the control mechanisms, which normally maintain a balance between the rate of proliferation and the rate of apoptosis (controlled cell death). Result shows that this model closes to clinical finding and can simulate brain tumor behavior properly.

Citation Download Citation

Hossein Yousefi Banaem, Alireza Ahmadian, Hooshangh Saberi, Alireza Daneshmehr, and Davood Khodadad "Brain tumor modeling: glioma growth and interaction with chemotherapy", Proc. SPIE 8285, International Conference on Graphic and Image Processing (ICGIP 2011), 82851M (30 September 2011); https://doi.org/10.1117/12.913432

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