Compact intraoperative imaging device for sentinel lymph node mapping

Yang Liu; Adam Q. Bauer; Walter Akers; Gail Sudlow; Kexian Liang; Duanwen Shen; Mikhail Berezin; Joseph P. Culver; Samuel Achilefu

doi:10.1117/12.886226

11 February 2011 Compact intraoperative imaging device for sentinel lymph node mapping

Yang Liu, Adam Q. Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Duanwen Shen, Mikhail Berezin, Joseph P. Culver, Samuel Achilefu

Author Affiliations +

Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 79100D (2011) https://doi.org/10.1117/12.886226
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We have developed a novel real-time intraoperative fluorescence imaging device that can detect near-infrared (NIR) fluorescence and map sentinel lymph nodes (SLNs). In contrast to conventional imaging systems, this device is compact, portable, and battery-operated. It is also wearable and thus allows hands-free operation of clinicians. The system directly displays the fluorescence in its goggle eyepiece, eliminating the need for a remote monitor. Using this device in murine lymphatic mapping, the SLNs stained with indocyanine green (ICG) can be readily detected. Fluorescence-guided SLN resection under the new device was performed with ease. Ex vivo examination of resected tissues also revealed high fluorescence level in the SLNs. Histology further confirmed the lymphatic nature of the resected SLNs.

Citation Download Citation

Yang Liu, Adam Q. Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Duanwen Shen, Mikhail Berezin, Joseph P. Culver, and Samuel Achilefu "Compact intraoperative imaging device for sentinel lymph node mapping", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100D (11 February 2011); https://doi.org/10.1117/12.886226

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