Homogeneous UVA system for corneal cross-linking treatment

Fernando Ramon Ayres Pereira; Mario Antônio Stefani; José Antônio Otoboni; Eduardo Henrique Richter; Liliane Ventura

doi:10.1117/12.842260

23 February 2010 Homogeneous UVA system for corneal cross-linking treatment

Fernando Ramon Ayres Pereira, Mario Antônio Stefani, José Antônio Otoboni, Eduardo Henrique Richter, Liliane Ventura

Proceedings Volume 7556, Design and Quality for Biomedical Technologies III; 75560Z (2010) https://doi.org/10.1117/12.842260
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The treatment of keratoconus and corneal ulcers by collagen cross-linking using ultraviolet type A irradiation, combined with photo-sensitizer Riboflavin (vitamin B2), is a promising technique. The standard protocol suggests instilling Riboflavin in the pre-scratched cornea every 5min for 30min, during the UVA irradiation of the cornea at 3mW/cm² for 30 min. This process leads to an increase of the biomechanical strength of the cornea, stopping the progression, or sometimes, even reversing Keratoconus. The collagen cross-linking can be achieved by many methods, but the utilization of UVA light, for this purpose, is ideal because of its possibility of a homogeneous treatment leading to an equal result along the treated area. We have developed a system, to be clinically used for treatment of unhealthy corneas using the cross-linking technique, which consists of an UVA emitting delivery device controlled by a closed loop system with high homogeneity. The system is tunable and delivers 3-5 mW/cm², at 365nm, for three spots (6mm, 8mm and 10mm in diameter). The electronics close loop presents 1% of precision, leading to an overall error, after the calibration, of less than 10% and approximately 96% of homogeneity.

Citation Download Citation

Fernando Ramon Ayres Pereira, Mario Antônio Stefani, José Antônio Otoboni, Eduardo Henrique Richter, and Liliane Ventura "Homogeneous UVA system for corneal cross-linking treatment", Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560Z (23 February 2010); https://doi.org/10.1117/12.842260

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KEYWORDS

Ultraviolet radiation

Cornea

3D image processing

Beam analyzers

Collagen

Tissues

Visualization

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