Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O2 in single red blood cell

Huihua Kenny Chiang; Hung-Shiang Ruan; Hung-You Cheng; Tung-Ting Fang

doi:10.1117/12.700380

6 February 2007 Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O₂ in single red blood cell

Huihua Kenny Chiang, Hung-Shiang Ruan, Hung-You Cheng, Tung-Ting Fang

Proceedings Volume 6430, Advanced Biomedical and Clinical Diagnostic Systems V; 64301A (2007) https://doi.org/10.1117/12.700380
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Raman spectroscopy has been shown to have the potential for providing oxygenated ability of erythrocytes. Raman line at 1638 cm-1 has also been reported as one significant oxygenic indicator for erythrocytes. In this research, we develop the Raman spectroscopic monitoring of the bioeffects of Nitroglycerin on hemoglobin oxygen saturation in a single red blood cell (RBC). Nitroglycerin has been frequently used in the management of angina pectoris. Nitroglycerin liberates nitric oxide (NO) to blood vessels. NO is an oxidizer that easily converts hemoglobin to methemoglobin. The conversion may cause the decrease of oxygenated ability of erythrocytes. In this study, we observed the oxidize state of erythrocytes caused by the over dosage of Nitroglycerin. When the dose of Nitroglycerin exceeds 2x10^-4 M, the oxygenic state of erythrocytes decreases significantly. The Raman spectroscopic results demonstrate the observation of the bioeffects of Nitroglycerin on hemoglobin.

Citation Download Citation

Huihua Kenny Chiang, Hung-Shiang Ruan, Hung-You Cheng, and Tung-Ting Fang "Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O₂ in single red blood cell", Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301A (6 February 2007); https://doi.org/10.1117/12.700380

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KEYWORDS

Raman spectroscopy

Blood

Spectroscopy

Blood vessels

Oxygen

Heart

NOx

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