FTIR study on the normal and malignant gastric tissues

Cungui Cheng; Bei Wang; Hinghai Liu; Peixi Zhu; Danting Li; Qingjie Chen

doi:10.1117/12.667469

2 February 2006 FTIR study on the normal and malignant gastric tissues

Cungui Cheng, Bei Wang, Hinghai Liu, Peixi Zhu, Danting Li, Qingjie Chen

Proceedings Volume 6026, ICO20: Biomedical Optics; 60261D (2006) https://doi.org/10.1117/12.667469
Event: ICO20:Optical Devices and Instruments, 2005, Changchun, China

Abstract

By experimenting with Fourier transform infrared spectroscopy (FTIR), it was found that FTIR yielded much better results and faster determination of normal and malignant gastric tissues when accompanied with OMNI-sampler. The results showed that there were obvious and regularity differences between FTIR spectra of them in spectral parameters such as frequency, intensity and shape of the bands etc. They indicated significant differences of content, structure and conformation of proteins, nucleic acids and lipids in normal and malignant gastric tissues. The probability found by the results of goodness-of-fit tests of frequency of the bands in the second derivative FTIR, between each of the normal and malignant gastric tissues was less than 0.01. This result was found to be significant. The present results suggested that FTIR could show the properties of normal and malignant gastric tissues in the molecular level. It contains the ability to supply rich and reliable information to investigation of normal and malignant gastric tissues and can be used as a convenient and reliable diagnostic tool for tumors.

Citation Download Citation

Cungui Cheng, Bei Wang, Hinghai Liu, Peixi Zhu, Danting Li, and Qingjie Chen "FTIR study on the normal and malignant gastric tissues", Proc. SPIE 6026, ICO20: Biomedical Optics, 60261D (2 February 2006); https://doi.org/10.1117/12.667469

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