Photoacoustic imaging of inhomogeneities embedded in breast tissue phantoms

Srirang Manohar; Alexei Kharine; Johan G.C. van Hespen; Wiendelt Steenbergen; Frits F. M. de Mul; Ton G. J. M. van Leeuwen

doi:10.1117/12.477778

1 July 2003 Photoacoustic imaging of inhomogeneities embedded in breast tissue phantoms

Srirang Manohar, Alexei Kharine, Johan G.C. van Hespen, Wiendelt Steenbergen, Frits F. M. de Mul, Ton G. J. M. van Leeuwen

Author Affiliations +

Proceedings Volume 4960, Biomedical Optoacoustics IV; (2003) https://doi.org/10.1117/12.477778
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

A novel photoacoustic breast phantom was developed using poly(vinyl alcohol) gel prepared by a simple technique that imparts optical scattering to the gel without the neccessity for scattering particles. Tumour simulating gel samples of suitable absorption coefficient were also prepared using a second technique, by adding appropriate quantities of dye at the time of formation; the samples were then cut into spheres. The optical absorption coefficient of the spheres was chosen as between 4 - 7 times that of breast tissue. A breast phantom with a thickness of 60 mm, embedded with such 'tumours' was developed for studying the applicability of photoacoustics in mammography. Time resolved photoacoustics, in a transmission mode, was used to image the inhomogeneities. Light excitation was from a liquid-light guide coupled Nd:YAG laser at 1064 nm, with a 5 ns pulse duration. The guide was mechanically scanned across the surface of the phantom, with the time-of-flight signals recorded using a PVDF based detector array. A modified delay and sum beamforming algorithm was used to reconstruct the photoacoustic sources. Results of these experiments are discussed.

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Srirang Manohar, Alexei Kharine, Johan G.C. van Hespen, Wiendelt Steenbergen, Frits F. M. de Mul, and Ton G. J. M. van Leeuwen "Photoacoustic imaging of inhomogeneities embedded in breast tissue phantoms", Proc. SPIE 4960, Biomedical Optoacoustics IV, (1 July 2003); https://doi.org/10.1117/12.477778

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