Tissue soldering with biodegradable polymer films: preliminary in-vivo compatibility test

Brian S. Sorg; Ashley J. Welch

doi:10.1117/12.430664

17 June 2002 Tissue soldering with biodegradable polymer films: preliminary in-vivo compatibility test

Brian S. Sorg, Ashley J. Welch

Proceedings Volume 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII; (2002) https://doi.org/10.1117/12.430664
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Previous in vitro laser-tissue welding research demonstrated a technique to improve the acute breaking strength of liquid albumin solder using biodegradable polymer film reinforcement. This study’s purpose was to explore what problems could arise in vivo that were not evident in vitro. Full thickness incisions were created on the dorsum of Sprague-Dawley rats. A poly(lactic-co-glycolic acid) (PLGA) film was subcutaneously implanted in the incision (controls had no film). The incisions were closed by laser-tissue welding: albumin solder with Indocyanine Green dye was inserted between the incision edges and coagulated with a diode laser. Specimens were harvested at 0, 3, 7, and 14 days for strength testing and histologic analysis. Histology indicated that the PLGA film was relatively well tolerated by the tissue. Breaking strengths of controls at 0 and 14 days were stronger than specimens with implanted films (t-test, P < 0.05). Difficulty apposing the incision edges due to the film presence probably contributed to low acute strengths. Interference with wound contraction by the films possibly contributed to lower breaking strengths at 14 days. Polymer films for patch reinforcement of solder may be clinically feasible; however, application specific problems can occur and should be considered when developing a clinical technique.

Citation Download Citation

Brian S. Sorg and Ashley J. Welch "Tissue soldering with biodegradable polymer films: preliminary in-vivo compatibility test", Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); https://doi.org/10.1117/12.430664

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