Two-photon process takes aim at diagnosis and therapy of cancer

Qirong Xing; Heying Wei; Lu Chai; Weili Zhang; Ning Zhang; Ching-yue Wang; Xuhong Miao; Yingxin Li

doi:10.1117/12.428014

29 May 2001 Two-photon process takes aim at diagnosis and therapy of cancer

Qirong Xing, Heying Wei, Lu Chai, Weili Zhang, Ning Zhang, Ching-yue Wang, Xuhong Miao, Yingxin Li

Proceedings Volume 4276, Commercial and Biomedical Applications of Ultrashort Pulse Lasers; Laser Plasma Generation and Diagnostics; (2001) https://doi.org/10.1117/12.428014
Event: Photonics West 2001 - LASE, 2001, San Jose, CA, United States

Abstract

We present a new method of diagnosing cancer, femtosecond laser in vivo HpD (haematoporphyrin derivatives) two-photon fluorescence, and observations of in vivo HpD two-photon fluorescence of cancer tissue of little mice using excitation of femtosecond laser pulse generated by self-mode-locked Ti:sapphire laser. The narrow pulse width, the high peak power of the excitation source and the central wavelength of 810 nm that is the window wavelength of biological tissue show that biomedical signal induced by this light source must have high signal-noise ratio. This femtosecond laser pulse and the two-photon fluorescence technique do no harm to normal tissue surrounding the cancer. The result of our experiments shows that the cancer tissue can be distinguished and diagnosed with the method of in vivo HpD two-photon fluorescence excited by femtosecond laser pulses with suitable wavelength.

Citation Download Citation

Qirong Xing, Heying Wei, Lu Chai, Weili Zhang, Ning Zhang, Ching-yue Wang, Xuhong Miao, and Yingxin Li "Two-photon process takes aim at diagnosis and therapy of cancer", Proc. SPIE 4276, Commercial and Biomedical Applications of Ultrashort Pulse Lasers; Laser Plasma Generation and Diagnostics, (29 May 2001); https://doi.org/10.1117/12.428014

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KEYWORDS

Luminescence

Cancer

Femtosecond phenomena

Tissues

In vivo imaging

Laser tissue interaction

Tissue optics

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