Wide-field high spatial frequency domain imaging of tissue microstructure

Weihao Lin; Bixin Zeng; Zili Cao; Danfeng Zhu; M. Xu

doi:10.1117/12.2289207

12 February 2018 Wide-field high spatial frequency domain imaging of tissue microstructure

Weihao Lin, Bixin Zeng, Zili Cao, Danfeng Zhu, M. Xu

Proceedings Volume 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI; 1048416 (2018) https://doi.org/10.1117/12.2289207
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Wide-field tissue imaging is usually not capable of resolving tissue microstructure. We present High Spatial Frequency Domain Imaging (HSFDI) - a noncontact imaging modality that spatially maps the tissue microscopic scattering structures over a large field of view. Based on an analytical reflectance model of sub-diffusive light from forward-peaked highly scattering media, HSFDI quantifies the spatially-resolved parameters of the light scattering phase function from the reflectance of structured light modulated at high spatial frequencies. We have demonstrated with ex vivo cancerous tissue to validate the robustness of HSFDI in significant contrast and differentiation of the microstructutral parameters between different types and disease states of tissue.

Citation Download Citation

Weihao Lin, Bixin Zeng, Zili Cao, Danfeng Zhu, and M. Xu "Wide-field high spatial frequency domain imaging of tissue microstructure", Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048416 (12 February 2018); https://doi.org/10.1117/12.2289207

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