A novel drug carrier based on functional modified nanofiber cellulose and the control release behavior

Xiangning Shi; Yudong Zheng; Wei Zhang; Zeyu Zhang; Yunling Peng

doi:10.1117/12.2027556

9 August 2013 A novel drug carrier based on functional modified nanofiber cellulose and the control release behavior

Xiangning Shi, Yudong Zheng, Wei Zhang, Zeyu Zhang, Yunling Peng

Proceedings Volume 8793, Fourth International Conference on Smart Materials and Nanotechnology in Engineering; 879304 (2013) https://doi.org/10.1117/12.2027556
Event: Fourth International Conference on Smart Materials and Nanotechnology in Engineering, 2013, Gold Coast, Australia

Abstract

This study developed a novel drug carrier based on functional modified bacterial cellulose(BC) which was conjugated with Ibuprofen(IBU) by esterification. BC-Ibuprofen as the macro- molecular prodrugs and drug carrier used to improve the short half-life of the drug, and was able to control release through the hydrolysis of ester bond between the hydroxyl groups of BC with Ibuprofen under different condition. Fourier transform infrared analysis revealed that Ibuprofen had been successfully grafted onto the bacterial cellulose (BC). Thermal and morphological characterization indicated the formation of the BC-Ibuprofen system incompletely reacted maintained the bulk structure of the pristine material such as crystallinity, 3-dimentional network and so on. The drug release behaviours were affected by the ester bond hydrolysis as well as the microstructure characteristics of the modified nanofiber. The release of BC-IBU showed an apparent pH-dependent, fast in alkaline and acid solution but slow relatively in neutral. Such pH-responsiveness, in addition to its morphological characteristics, in this paper suggested a great potential of BC-IBU as a more effective, safe, and stable prodrug candidate.

Citation Download Citation

Xiangning Shi, Yudong Zheng, Wei Zhang, Zeyu Zhang, and Yunling Peng "A novel drug carrier based on functional modified nanofiber cellulose and the control release behavior", Proc. SPIE 8793, Fourth International Conference on Smart Materials and Nanotechnology in Engineering, 879304 (9 August 2013); https://doi.org/10.1117/12.2027556

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available