Microbeam radiation therapy

Jean A. Laissue; Nadia Lyubimova; Hans-Peter Wagner; David W. Archer; Daniel N. Slatkin M.D.; Marco Di Michiel; Christian Nemoz; Michel Renier; Elke Brauer; Per O. Spanne; Jan-Olef Gebbers; Keith Dixon; Hans Blattmann

doi:10.1117/12.368185

6 October 1999 Microbeam radiation therapy

Jean A. Laissue, Nadia Lyubimova, Hans-Peter Wagner, David W. Archer, Daniel N. Slatkin M.D., Marco Di Michiel, Christian Nemoz, Michel Renier, Elke Brauer, Per O. Spanne, Jan-Olef Gebbers, Keith Dixon, Hans Blattmann

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Proceedings Volume 3770, Medical Applications of Penetrating Radiation; (1999) https://doi.org/10.1117/12.368185
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1999, Denver, CO, United States

Abstract

The central nervous system of vertebrates, even when immature, displays extraordinary resistance to damage by microscopically narrow, multiple, parallel, planar beams of x rays. Imminently lethal gliosarcomas in the brains of mature rats can be inhibited and ablated by such microbeams with little or no harm to mature brain tissues and neurological function. Potentially palliative, conventional wide-beam radiotherapy of malignant brain tumors in human infants under three years of age is so fraught with the danger of disrupting the functional maturation of immature brain tissues around the targeted tumor that it is implemented infrequently. Other kinds of therapy for such tumors are often inadequate. We suggest that microbeam radiation therapy (MRT) might help to alleviate the situation. Wiggler-generated synchrotron x-rays were first used for experimental microplanar beam (microbeam) radiation therapy (MRT) at Brookhaven National Laboratory's National Synchrotron Light Source in the early 1990s. We now describe the progress achieved in MRT research to date using immature and adult rats irradiated at the European Synchrotron Radiation Facility in Grenoble, France, and investigated thereafter at the Institute of Pathology of the University of Bern.

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Jean A. Laissue, Nadia Lyubimova, Hans-Peter Wagner, David W. Archer, Daniel N. Slatkin M.D., Marco Di Michiel, Christian Nemoz, Michel Renier, Elke Brauer, Per O. Spanne, Jan-Olef Gebbers, Keith Dixon, and Hans Blattmann "Microbeam radiation therapy", Proc. SPIE 3770, Medical Applications of Penetrating Radiation, (6 October 1999); https://doi.org/10.1117/12.368185

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