Measuring the biomechanical properties of prostate tumor tissues by atomic force microscopy

Xiaoqiong Tang; Weiwei Ruan; Jinshu Zeng; Mengdan Chen; Yuhua Wang; Hongqin Yang

doi:10.1117/12.2548958

20 December 2019 Measuring the biomechanical properties of prostate tumor tissues by atomic force microscopy

Xiaoqiong Tang, Weiwei Ruan, Jinshu Zeng, Mengdan Chen, Yuhua Wang, Hongqin Yang

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 112093S (2019) https://doi.org/10.1117/12.2548958
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

Tumor progression and metastasis are often accompanied by the changes in the biomechanical properties of tumor tissues. In this study, the relationship between the pathological classification of different prostate tumor tissues and their biomechanical properties was investigated by atomic force microscopy. The results showed that higher pathological grade of prostate tumor tissues had lower elasticity and viscosity. Compared with traditional pathological analysis, the biomechanical characteristics of tumor tissues obtained by atomic force microscopy could offer a new index for fast clinic diagnosis and differentiation of tumor tissue. It can be used to assist in the assessment of Gleason scores of the gold standard for prostate cancer grading for radical prostatectomy.

Citation Download Citation

Xiaoqiong Tang, Weiwei Ruan, Jinshu Zeng, Mengdan Chen, Yuhua Wang, and Hongqin Yang "Measuring the biomechanical properties of prostate tumor tissues by atomic force microscopy", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 112093S (20 December 2019); https://doi.org/10.1117/12.2548958

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