Effect of data pretreatment on the noninvasive blood glucose measurement by diffuse reflectance NIR spectroscopy

Herbert Michael Heise; Ralf Marbach

doi:10.1117/12.166662

31 January 1994 Effect of data pretreatment on the noninvasive blood glucose measurement by diffuse reflectance NIR spectroscopy

Herbert Michael Heise, Ralf Marbach

Author Affiliations +

Proceedings Volume 2089, 9th International Conference on Fourier Transform Spectroscopy; (1994) https://doi.org/10.1117/12.166662
Event: Fourier Transform Spectroscopy: Ninth International Conference, 1993, Calgary, Canada

Abstract

Recent progress in spectroscopy and chemometrics have brought in-vitro blood glucose analysis into clinical reach. Parallel to these efforts noninvasive experiments by NIR- spectroscopy have also been proposed and carried out. A specially designed and optimized accessory for diffuse reflectance measurements in the spectral range of 9000 - 5000 cm^-1 was used. The spectral data and reference concentration values were obtained using oral glucose tolerance tests. Calibration results are provided for log(1/R) and single beam spectra. In addition, the effects of smoothing and the use of derivative filtering were evaluated. The best results were achieved by multivariate PLS-modeling with raw data from single beam reflectance spectra.

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Herbert Michael Heise and Ralf Marbach "Effect of data pretreatment on the noninvasive blood glucose measurement by diffuse reflectance NIR spectroscopy", Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); https://doi.org/10.1117/12.166662

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