Parenteral nutrition (PN) has been a major advances in the nutritional care of infants and children, However, a number of complications associated with this form of nutrition have been identified, including technical and metabolic complications. During the past 18 years period (1970-1988), a total of 464 patients (137 neonates, 162 infants And 165 children) were placed on PN in our Department, These 464 patients were divided into two groups according to the basic stages in management of PN ; Group 1 : 1970-1980,Group 2 ; 1981-1988 and clinical result, particularly the incidence of complications, was investigared and the following results were obtained; 1, The incidence of technical complications due to placement and position of central venous catheter for PN has been reduced significantly in Group 2 by strict attention to aseptic technique and by introduction of nonreactive silicone catheters. 2, However, hepatic dysfunction remaines one of the most common and most serious complications of PN in both groups, showing no difference in incidence of PN-assosiated liver complications between two groups.