Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Comparison of Efficacy on Powder and Tablet of Mebendazole in the Treatment of Strongyloidiasis
Koushin SHIKIYANagisa KINJOMinoru IKEMAAkihiro YAMASHIROHiroyuki UECHITominori OYAKAWAFukunori KINJOAtsushi SAITOHiroshi NAKAMURATomohisa OHWANMasato YAMASHIRORyuji ASATO
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1991 Volume 65 Issue 6 Pages 681-686

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Abstract

We previously treated 47 patients with 100 mg of mebendazole (MBZ) twice a day by oral use for 5 days and this treatment was repeated 1, 3 and 4 weeks later. Although the cure rate was 100%, liver injury was observed in 48.9% of the patients. On this study, we reduced the periods of administration of MBZ (powder; 100 mg twice a day) to 4 days, and repeated it once after 3 days interval, and this initial treatment was performed one more time after 10 days interval (group 1).
As Strongyloides stercoralis is mainly located in upper digestive systems, we used the drug reduced to powder for the purpose of better contact with the parasites. We considered that the powder should be absorbed well and liver injury occurred in high incidence.
As group 2, we used the tablet itself in the same schedules of group 1.
The results obtained were as follows;
1) The eradication rates at 10 days after the initial treatment were 97.8%(44 of 45 patients) in group 1 (powder) and 93.0%(40/43) in group 2 (tablet).
2) At 3 days after the whole treatment, the eradication rates were 100.0% in group 1, and 97.7%(42/43) in group 2.
3) Slight side effects such as constipation (6.7% in the group 1), dizziness or vertigo (6.7% in the group 1) and itching (6.7% in the group 2) were observed.
4) Liver injury was observed at 11.1%(5/45) 10 days after the initial treatment in the group 1 and 13.3%(6/45) in the group 2. After whole treatment, it was observed at 60.0%(27/45) and 68.9%(31/45) in the both groups, respectively.
In comparison of the two groups, there were no significant differences of HTLV-1 antibody positive rate and improvement of symptoms, side effects, eradication rate of the parasite and incidence of liver injury after the treatment, but significant difference was obtained in liver function between examination after the initial treatment and the whole treatment in the both groups.
As conclusion, tablet or powder of MBZ could be used either with safe and satisfactory eradication in the initial treatment, i.e. in dosis of 100 mg, twice a day for 4 days and this treatment repeated after 3 days interval.

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© The Japansese Association for Infectious Diseases
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