Clinical effect of long-acting preparation of Cephalexin (S-6436) was investigated in comparison with Cephalexin at the identical dosage of 1, 000mg/day under the double blind test on adult patients with acute tonsillitis or acute otitis media.
The administration frequency was planned as twice a day in S-6436 and 4 times a day in Cephalexin with aid of placebo, and the following results were obtained.
1. In the treatment of 65 patients with acute tonsillitis, clinical improvement was observed in 87.5% on S-6436 group and 88.5% on Cephalexin group.
Statistical analysis revealed no significant difference between these two groups.
2. In acute otitis media, statistical analysis was impossible for lack of sufficient cases, but no difference in effectiveness was seen between two groups.
3. As the side effect, vomitting was observed in one case treated with cephalexin, but there was no adverse reaction in S-6436 group.
4. From the above results, it is concluded that S-6436 to be taken twice a day is equivalent to Cephalexin in effectiveness for acute tonsillitis and acute otitis media.