With progress in chemotherapy, typhoid fever has failed to come up with not only typical clinical features, but also marked elevation of antibody titers, We studied Widal reaction with 2ME treatment sera and try to evaluate the clinical meaning of Widal reaction. Two hundred and fifty three samples from 33 patients and 8 carriers were examined.
The results were summarized as follows;
1. In patients, Vi-and O-antibody was belonging to the IgM class in the initial stage of hospitalization.
2. In carriers, Vi-and O-antibody was belonging to the IgG class in the initial stage of hospitalization.
3. In bacillary negative patients, Vi-titer showed 1: IO and O-titer maintained low levels.
4. V-antibody titer more correlated with bacterial excretion than O-antibody titer. When patients were re-excreting bacteria, Vi-antibody belonging to IgM was appeared.