Nitric Oxide Ventilation of Rat Lungs from Non-Heart-Beating Donors Improves Posttransplant Function
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Key words
Actin cytoskeleton
assessment
ex vivo assessment
experimental transplantation
graft function
ischemia/reperfusion injury
lung transplantation
MAP kinase
nitric oxide
non-heart-beating donors
nuclear factor-kappa B (NF-κB)
pulmonary vascular physiology
rat
TNF-alpha
Abbreviations:
cGMP
cyclic guanosine monophosphate
ERK
extracellular signal-regulated kinases
HMVECs
human pulmonary microvascular endothelial cells
HUVECs
human umbilical vein endothelial cells
IRI
ischemia-reperfusion injury
LTX
lung transplantation
MAPK
mitogen-activated protein kinase
NHBD
non-heart-beating donor
NF-κB
nuclear kappa factor B
NO
nitric oxide
NOS
nitric oxide synthase
eNOS
endothelial NOS
iNOS
inducible NOS
nNOS
neuronal NOS
p38
p38-MAPK
PA
pulmonary artery
PVR
pulmonary vascular resistance
SAPK/JNKs
stress-activated/c-Jun NH2-terminal kinases
TNF-α
tumor necrosis factor alpha
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Copyright © 2009 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.