Copper‐Carbohydrate Interaction: Part I

Recent studies have shown that the type of dietary carbohydrate consumed greatly affects copper homeostasis. Simple sugars such as sucrose and fructose exacerbate the signs associated with the deficiency, and the consumption results in the mortality of the animal. In contrast, complex carbohydrates such as starch ameliorates the deficiency and protects against the morbidity and mortality of copper deficiency. This is the first of a two‐part article in which the effects of dietary carbohydrates on metabolic, biochemical and physiological pathways associated with copper deficiency in experimental animals and humans are summarised. In the first part of the review the effects that dietary carbohydrates exert on copper absorption, distribution and excretion are discussed. In addition, the role that copper plays in carbohydrate metabolism, insulin secretion and binding, glucose tolerance and the complications of diabetes (retinopathy and glomerular nephropathy) is reviewed. In the second part, the attention is focused on the cardiovascular system, sexual differences in copper‐carbohydrate interaction and copper deficiency during pregnancy and lactation. The mechanisms that may play a role in this interaction are discussed.