Three-dimensional structures of RNA obtained by means of knowledge-based interaction potentials

Oscar Taxilaga-Zetina, Patricia Pliego-Pastrana, and Mauricio D. Carbajal-Tinoco
Phys. Rev. E 81, 041914 – Published 19 April 2010
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Abstract

We derive a set of effective potentials describing the interaction between pairs of nucleotides that belong to an RNA molecule. Such interaction potentials are then used as the main constituents of a simplified simulation model, which is tested in the description of small secondary structure motifs. Our simulated RNA hairpins are consistent with the experimental structures obtained by NMR.

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  • Received 21 July 2009

DOI:https://doi.org/10.1103/PhysRevE.81.041914

©2010 American Physical Society

Authors & Affiliations

Oscar Taxilaga-Zetina, Patricia Pliego-Pastrana, and Mauricio D. Carbajal-Tinoco

  • Departamento de Física, Centro de Investigación y de Estudios Avanzados del IPN, Apartado Postal 14-740, 07000 México, Distrito Federal, Mexico

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Issue

Vol. 81, Iss. 4 — April 2010

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